Results 91 to 100 of about 305,369 (273)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Catching Em Young To Tackle Prejudices [PDF]

open access: yes, 2008
A STUDENT leader of a public university was recently reported to have written a racially in flammatory statement calling on some groups to be prepared for any eventuality in light of the country s political ...
New Straits Times, Chok Suat Ling
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Conciliar lo laboral y doméstico: un reto para la sociedad cubana actual / Reconciling the Work and the Household Domains: a Challenge for Today’s Cuban Society

open access: yesAsparkía, 2009
RESUMEN: Se analiza con elementos concretos cómo en Cuba a partir del primero de enero de 1959 la situación de la sociedad cubana cambió profundamente y en particular la de la mujer.
Maribel Almaguer Rondón
doaj  

Childhood stuttering

open access: yesListy klinicke logopedie, 2021
The article gives a historical overview and the state of the art concerning childhood stuttering. It deals with the well-established and recommended methods of treating stuttering and of advising parents.
Patricia Sandrieser
doaj  

The Subjectivity of Effective History and the Suppressed Husserlian Elements in Gadamer’s Philosophical Hermeneutics [PDF]

open access: yes, 2007
This essay makes two claims. The first, exegetical, point shows that there are Husserlian elements in Gadamer’s hermeneutics that are usually overlooked.
Luft, Sebastian
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

innovation, employee control, efficiency, resistance to social change, dirty work

open access: yesBulletin of the Transilvania University of Braşov: Series VII: Social Sciences, Law
This article presents the theoretical framework and the results of a research conducted in a brewery with respect to the concept of gender discrimination. The main objective of the research is to identify gender inequalities and
Ada Ioana Dobrescu
doaj   +1 more source

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