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СОВРЕМЕННОЕ СОСТОЯНИЕ ПЕРВИЧНОГО ПРОЕКТИРОВАНИЯ НА ПРИМЕРЕ ЦЕНТРОБЕЖНЫХ КОМПРЕССОРОВ ТУРБОДЕТАНДЕРНЫХ АГРЕГАТОВ

Cifra: Машиностроение
Цифровизация технологических процессов привела к тому, что заказчики турбодетандерных агрегатов с центробежными компрессорами требуют обеспечить расчет газодинамических характеристик компрессоров и требования технического задания к потребляемой мощности ...
Рекстин А.Ф., Галеркин Ю.Б., Бабиченко И.А., Михайлов А.А., Соколов К.К., Семеновский В.Б.   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3mP Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM3P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the ...
R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F. J. de Jong, E. G. P. Dopper, P. A. E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer   +16 more
wiley   +1 more source

Conceptual Design of a Hybrid-Electric Aircraft Based on a Dornier 328 Demonstrator

Aerospace
Air travel contributed 3.5% to global warming in 2020, with a rising tendency. Only one third of the climate impact is caused by CO2. Other exhaust gases that cause harm to the climate are nitrogen oxides, soot, and water vapor, creating contrails with a
Annika Nora Staats, Florian Troeltsch, Andreas Bardenhagen   +2 more
doaj   +1 more source

Preliminary design of an innovative, simple, and easy-to-build portable ventilator for COVID-19 patients. [PDF]

EuroMediterr J Environ Integr, 2020
El Majid B, El Hammoumi A, Motahhir S, Lebbadi A, El Ghzizal A.   +4 more
europepmc   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

A Revised Shear Panel Formulation for Parallelogram Panels

Aerospace
The growing complexity of large-scale, thin-walled structures can be managed through the use of hierarchical modelling approaches. In aeroelastic wing design, efficient models are needed during the concept and preliminary design phases, as a large design
Moritz Bäß, Kai-Uwe Schröder
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Operability Implications of Speed Variability in Hybridised Vaneless Counter-Rotating Axial Compressor Concepts

Aerospace
The aviation sector faces the challenge of reducing emissions while meeting growing demand for passenger transport. Recent research has proposed a hybridised axial compressor concept using a vaneless, counter-rotating configuration with independently ...
Jan Nittka, Dieter Peitsch
doaj   +1 more source