Advanced Science, EarlyView.Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie +12 more
wiley +1 more source
Development and Preliminary Evaluation of a Questionnaire on Parental Informed Consent in Neonatal Research. [PDF]
Children (Basel)Lampridou M +9 more
europepmc +1 more source
Advanced Science, EarlyView.Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu +4 more
wiley +1 more source
Interpreting Gastrointestinal Recovery After Tegileridine-Based PCIA in Elderly Colorectal Surgery Patients [Letter]. [PDF]
Drug Des Devel TherQiu C.
europepmc +1 more source
Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo
Advanced Science, EarlyView.By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang +9 more
wiley +1 more source
Touch imprint cytology: a practical step toward standardized rapid on-site evaluation. [PDF]
Clin EndoscChoi SJ.
europepmc +1 more source
Advanced Science, EarlyView.Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang +5 more
wiley +1 more source
GCMembrane-LLM: An Evidence-Grounded Domain-Specific Large Language Model for Structure-Performance Reasoning in Graphene and Carbon Nanotube Separation Membranes. [PDF]
Membranes (Basel)Liu Y +7 more
europepmc +1 more source
Advanced Science, EarlyView.Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu +4 more
wiley +1 more source
Short-term safety and preliminary patient-reported outcomes of bipolar radiofrequency therapy for mild-to-moderate erectile dysfunction: a prospective single-arm pilot study. [PDF]
Transl Androl UrolValenzuela RJ +4 more
europepmc +1 more source