Results 181 to 190 of about 36,161 (264)

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista   +11 more
wiley   +1 more source

A Novel Abutment Screw Head Design with an Integrated Retrieval Feature: An In Vitro Study. [PDF]

open access: yesDent J (Basel)
Batista R   +4 more
europepmc   +1 more source

Myocardial stretch‐induced ROS production is enhanced prior to the development of heart failure under TAC‐induced pressure overload

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend To elucidate the relationship between oxidative stress in heart failure induced by chronic mechanical overload and physiological NOX2‐derived stretch‐induced reactive oxygen species (ROS) that support myocardial contractility during acute stretch, we investigated the changes in stretch‐induced ROS following transverse aortic ...
Yumiko Chiba   +4 more
wiley   +1 more source

The Role of PoCUS in the Diagnosis and Early Monitoring of Cardiogenic Shock in the Emergency Department: A Narrative Review. [PDF]

open access: yesRev Cardiovasc Med
Giovenali L   +7 more
europepmc   +1 more source

Dyssynchrony without dysfunction: Left bundle branch block does not acutely reduce cardiac output

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Six electromechanical in silico heart models were simulated under healthy and pure acute left bundle branch block (LBBB) conditions. LBBB induced electrical dyssynchrony and increased left ventricular free wall strain, while the right and left ventricular ejection fraction remained relatively unchanged.
Carola Kruthoff   +6 more
wiley   +1 more source

A deeper dip? Hot‐water immersion and nocturnal blood pressure regulation

open access: yes
Experimental Physiology, EarlyView.
Brendon H. Roxburgh, Kate N. Thomas
wiley   +1 more source

Slow calcium removal contributes to impaired lusitropic response to β‐adrenergic stimulation in HFpEF mice

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure, yet major gaps remain in our understanding of its underlying mechanisms, disease progression and effective treatment strategies. Mice with HFpEF exhibited exercise intolerance and diastolic dysfunction in vivo, while isolated hearts ...
Tamzin Zawadzki   +6 more
wiley   +1 more source

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