Results 71 to 80 of about 850,132 (317)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Death certificate: Premature Baby Tallifero
, 1922 This is a photograph of the death certificate for Premature Baby Tallifero, deceased on 1922-10-19, filed with the Arkansas Department of Health by the Ruebel Funeral Home in Little Rock.Transcribed.
Ruebel Funeral Home (Little Rock, Ark.)
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Experiences of fathers with inpatient premature neonates: Phenomenological interpretative analysis
Iranian Journal of Nursing and Midwifery Research, 2018 Background: Birth and hospitalization of premature neonates create enormous challenges for the family with serious impacts on parents' mental and emotional health.
Tahmineh Dadkhahtehrani +3 more
doaj +1 more source
Maternal Stressor Agents with Premature Infants in Neonatal Intensive Care Units [PDF]
Introduction: Birth of a premature infant is associated with separation from family and hospitalizationActually, parents would undergo a lot of stress. The present study aimed to determine stressor agents of the mothers with premature infants admitted ...
مهرنوش, نسرین +3 more
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, 2010 BACKGROUND: We examined the role of socio-economic status (SES) and marital status in premature mortality among working-age Russian males. Life expectancy among this group dropped sharply following the collapse of the Soviet Union and has yet to recover ...
Saburova, Lyudmila +4 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 2007 BACKGROUND: Cerebral abscesses are extremely rare in neonates. Serratia marcescens is an unusual cause of sepsis and neurological spread is especially ominous.
Tatiana Mattos Hirooka +4 more
doaj +1 more source
Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches [PDF]
, 2019 Background: Prognostic modelling using standard methods is well-established, particularly for predicting risk of single diseases. Machine-learning may offer potential to explore outcomes of even greater complexity, such as premature death.
Luis Vaz +11 more
core +1 more source