Results 101 to 110 of about 418,363 (219)

Predicting premature termination within a randomized controlled trial for binge-eating patients

, 2011
Understanding the dropout rates of efficacious forms of psychotherapy for patients with binge eating disorder (BED) is an unsolved problem within this increasing population.
Munsch, Simone, Messerli-Bürgy, N., Andrea Meyer, Gassmann, Daniel, Wampold, Bruce E., Flückiger, Christoph, Messerli-Bürgy, Nadine, Bruce E. Wampold, Wampold, B. E., Munsch, S., Nadine Messerli-Bürgy, Meyer, A. H., Wampold, Bruce E, Christoph Flückiger, Flückiger, C., Gassmann, D., Meyer, Andrea, Daniel Gassmann, Simone Munsch   +18 more
core   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Codon Usage Domains over Bacterial Chromosomes [PDF]

, 2006
The geography of codon bias distributions over prokaryotic genomes and its impact upon chromosomal organization are analyzed. To this aim, we introduce a clustering method based on information theory, specifically designed to cluster genes according to ...
Danchin, Antoine, Vergassola, Massimo, Marc Bailly-Bechet, Marsili, Matteo, Bailly-Bechet, Marc, Antoine Danchin, Mudassar Iqbal, Matteo Marsili, Iqbal, Mudassar; id_orcid, Marsili, Metteo, Massimo Vergassola, Iqbal, Musaddar   +11 more
core   +2 more sources

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source

Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis. [PDF]

Cochrane Database Syst Rev, 2023
Aslam AA, Sinha IP, Southern KW.
europepmc   +1 more source

Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. [PDF]

, 2008
BACKGROUND: Different proteins are required in widely different quantities to build a living cell. In most organisms, transcription control makes a major contribution to differential expression.
Horn, David, Horn, David; id_orcid, Horn David   +2 more
core   +1 more source

Autonomous Control of Gene Expression Using Endogenous Transcription Signals

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Autonomous cell‐based control of heterologous gene expression can simplify batch‐culture bioprocessing by eliminating external monitoring and extrinsic control of culture conditions. Existing approaches use auto‐induction media, synthetic cell‐cell communication systems, or application‐specific biosensors.
Pakpoom Subsoontorn, Drew Endy, Olivier Borkowski   +2 more
wiley   +1 more source

393 Harnessing the potential of transcriptional adaptation as a mechanism for rare Amyotrophic lateral sclerosis

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Transcriptional adaptation is a phenomenon in which a mutation in one gene leads to the genetic compensation of another homogenous gene.
Adriana Morales Gomez, Nathan Staff, Stephen C. Ekker   +2 more
doaj   +1 more source

Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion

Chemistry – A European Journal, EarlyView.
An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang, Nemanja Djokovic, Alexander Herr, Anna Wacker, Emily Swanson Hay, Daniel Santana, Amanda E. Hargrove, Harald Schwalbe, Katarina Nikolic, Frank Abendroth, Olalla Vázquez   +10 more
wiley   +1 more source

A Simple and Affordable Method to Create Nonsense Mutation Clones of p53 for Studying the Premature Termination Codon Readthrough Activity of PTC124. [PDF]

Biomedicines, 2023
Chen CC, Liao RY, Yeh FY, Lin YR, Wu TY, Pastor AE, Zul DD, Hsu YC, Wu KY, Liu KF, Kannagi R, Chen JY, Cai BH.   +12 more
europepmc   +1 more source