Results 61 to 70 of about 418,363 (219)

Unexpected correlations between gene expression and codon usage bias from microarray data for the whole Escherichia coli K-12 genome [PDF]

, 2003
Escherichia coli has long been regarded as a model organism in the study of codon usage bias (CUB). However, most studies in this organism regarding this topic have been computational or, when experimental, restricted to small datasets; particularly poor
Savva, Renos, Wernisch, Lorenz, dos Reis, M.   +2 more
core   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Structural features in the Rous sarcoma virus RNA stability element are necessary for sensing the correct termination codon

Retrovirology, 2010
Background Nonsense-mediated mRNA decay (NMD) is an mRNA quality control mechanism that selectively recognizes and targets for degradation mRNAs containing premature termination codons.
Withers Johanna B, Beemon Karen L
doaj   +1 more source

Multiple strategies to prevent premature termination in psychotherapy

, 2015
A Review of Premature Termination in Psychotherapy: Strategies for Engaging Clients and Improving Outcomes by Joshua K. Swift and Roger P. Greenberg Washington, DC: American Psychological Association. 2015. 212 pp, ISBN 978-1-4338-1801- 1.
Flückiger, Christoph
core   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Cotranscriptional effect of a premature termination codon revealed by live-cell imaging

, 2011
Aberrant mRNAs with premature translation termination codons (PTCs) are recognized and eliminated by the nonsense-mediated mRNA decay (NMD) pathway in eukaryotes.
Rodolfo Zamudio Orozco, Robert H. Singer, Mühlemann, Oliver, Zamudio Orozco, Rodolfo, Pamela Nicholson, Nicholson, Pamela, de Turris, Valeria, Valeria de Turris, Oliver Mühlemann, Singer, Robert H.   +9 more
core   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Extended stop codon context predicts nonsense codon readthrough efficiency in human cells

Nature Communications
Protein synthesis terminates when a stop codon enters the ribosome’s A-site. Although termination is efficient, stop codon readthrough can occur when a near-cognate tRNA outcompetes release factors during decoding.
Kotchaphorn Mangkalaphiban, Lianwu Fu, Ming Du, Kari Thrasher, Kim M. Keeling, David M. Bedwell, Allan Jacobson   +6 more
doaj   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin

Frontiers in Genetics
Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate incorporation of amino acids at the stop codon and production of full-length, often ...
Kamila Pawlicka, Tomas Henek, Lukas Uhrik, Lenka Hernychova, Monikaben Padariya, Jakub Faktor, Sławomir Makowiec, Borivoj Vojtesek, Borivoj Vojtesek, David Goodlett, Ted Hupp, Ted Hupp, Umesh Kalathiya   +12 more
doaj   +1 more source