Results 231 to 240 of about 77,977 (289)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

KDM2B‐Related Neurodevelopmental Disorder A Case‐Series Supporting the CxxC Domain Phenotype With Emphasis on Ocular and Dermatologic Features

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1098-1104, May 2026.
ABSTRACT The KDM2B‐related neurodevelopmental disorder is a recently identified Mendelian disorder of the epigenetic machinery associated with pathogenic variants in KDM2B. Global developmental delay, intellectual disability, congenital anomalies, and systemic manifestations characterize the disorder.
Adriana Gomes, Álvaro Martín‐Rodríguez, Miguel Del Campo, Lynne M. Bird   +3 more
wiley   +1 more source

Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Elevated amyloid beta (Aβ) levels and aggregation contribute to neurotoxicity and development of Alzheimer's disease (AD), the leading cause of dementia in the elderly. While we reported that native poly(D,L‐lactic‐co‐glycolic acid) (PLGA) nanoparticles, clinically used in drug delivery, suppress Aβ aggregation/toxicity, their ...
Govindarajan Karthivashan, Shuai Wang, Qi Wu, Abhishek Dahal, Xiuju Li, Danny Galleguillos, Simonetta Sipione, Gopal Thinakaran, Satyabrata Kar   +8 more
wiley   +1 more source

Beyond the Thrombus: Imaging‐Guided Management of Acute Coronary Syndrome

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Imaging‐guided management of acute coronary syndrome. ABSTRACT Intracoronary imaging is a true game‐changer in acute coronary syndromes, enhancing diagnostic accuracy while ensuring precise, mechanism‐driven, and patient‐tailored management.
Guillaume Guebey, Mathieu Chong, Adelin Barrier, Sarah Mauler‐Wittwer, Stéphane Noble, Quentin Liabot   +5 more
wiley   +1 more source

Zero-fluoroscopy approach for radiofrequency catheter ablation of left-sided, idiopathic ventricular arrhythmias – feasibility, efficacy, and safety evaluation

Advances in Interventional Cardiology
Dariusz Rodkiewicz, Karol Momot, Edward Koźluk, Agnieszka Piątkowska, Przemysław Kwasiborski, Małgorzata Buksińska-Lisik, Artur Mamcarz   +6 more
doaj   +1 more source

Delayed Efficacy of Radiofrequency Catheter Ablation in Intramural Ventricular Arrhythmias: Implications for Timing of Repeat Ablation and ICD Implantation

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Delayed efficacy of radiofrequency catheter ablation may occur in intramural ventricular arrhythmias due to progressive lesion maturation rather than immediate procedural failure. Recognizing this phenomenon may prevent premature repeat ablation or implantable cardioverter‐defibrillator (ICD) implantation.
Chukwuka Elendu, Nwachukwu O. Nwachukwu, Courage O. Idahor, Chimaobi Nwevo, Nwamaka Chidera Bob‐Ume, Ebuka C. Ezeh   +5 more
wiley   +1 more source

Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease

European Journal of Immunology, Volume 56, Issue 5, May 2026.
This study showed dysregulated αβ T cell homeostasis with ongoing T cell activation and low‐grade inflammation in 5‐12‐year‐old CHD children who underwent early‐life cardiac surgery with thymectomy, characterized by reduced naïve T cells and increased memory/effector and senescent‐like T cells.
Yusuf Eshimutu Abu, Christoph Kammeyer, Tao Yang, Rodrigo Gutierrez Jauregui, Alexa Cramer, Claudia Junge, Svea Kleiner, Anika Janssen, Adan Chari Jirmo, Alexander Horke, Reinhold Förster, Philipp Beerbaum, Martin Boehne, Sarina Ravens   +13 more
wiley   +1 more source

Sildenafil helps the beat go on

Experimental Physiology
Jules C. Hancox
doaj   +1 more source

Erratum: An observational study on the effect of premature ventricular complex burden on long-term outcome: Erratum. [PDF]

Medicine (Baltimore), 2017
europepmc   +1 more source