Results 91 to 100 of about 614,591 (385)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Rapid Assessment of the Quality of Neonatal Healthcare in Kilimanjaro Region, Northeast Tanzania. [PDF]

, 2012
While child mortality is declining in Africa there has been no evidence of a comparable reduction in neonatal mortality. The quality of inpatient neonatal care is likely a contributing factor but data from resource limited settings are few. The objective
AB Pembe, AS Nyamtema, Bernard Mbwele, C Klingenberg, C Opondo, CA Petti, CA Petti, CR Polage, D Acolet, DE Dow, E Ahman, Elizabeth Reddy, H Reyburn, HL Kidanto, HL Kidanto, Hugh Reyburn, J Newman, JE Lawn, JE Lawn, JK Rajaratnam, JM Belizan, K Gross, K Gross, K Manji, L Liu, LF Mott, M English, M English, M Mrisho, M Sarker, N Iriya, N Opiyo, R Lozano, SC Anyangwe, SG Hinderaker, SK Gaise, T Duke, UNICEF, United Nations Development Programme UNDP Tanzania, World Health Organization, World Health Organization, World Health Organization, ZA Bhutta   +42 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

International Classification of Retinopathy of Prematurity, Third Edition.

Ophthalmology (Rochester, Minn.), 2021
M. Chiang, G. Quinn, A. Fielder, S. Ostmo, R. V. Paul Chan, A. Berrocal, G. Binenbaum, M. Blair, J. Peter Campbell, A. Capone, Y. Chen, S. Dai, A. Ells, B. Fleck, W. Good, M. Elizabeth Hartnett, G. Holmstrom, S. Kusaka, A. Kychenthal, D. Lepore, B. Lorenz, M. Martinez-Castellanos, Ş. Özdek, D. Ademola-Popoola, J. Reynolds, P. Shah, M. Shapiro, A. Stahl, C. Toth, A. Vinekar, L. Visser, D. Wallace, Wei-Chi Wu, Peiquan Zhao, A. Zin   +34 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Inhaled nitric oxide in premature infants: effect on tracheal aspirate and plasma nitric oxide metabolites. [PDF]

, 2010
ObjectiveInhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study designA ...
Ballard, PL, Ballard, RA, Cnaan, A, Golombek, SG, Gow, AJ, NO CLD Investigators, Posencheg, MA, Truog, WE   +7 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010

Pediatric Research, 2013
Background:Retinopathy of prematurity (ROP) is a leading cause of potentially avoidable childhood blindness worldwide. We estimated ROP burden at the global and regional levels to inform screening and treatment programs, research, and data priorities ...
H. Blencowe, J. Lawn, T. Vázquez, A. Fielder, C. Gilbert   +4 more
semanticscholar   +1 more source

Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. [PDF]

, 2019
Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood.
Ackerman, William E, Brockway, Heather M, Buhimschi, Catalin S, Buhimschi, Irina A, Jones, Helen N, Kallapur, Suhas G, Muglia, Louis J   +6 more
core   +3 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source