Results 91 to 100 of about 36,439 (221)

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

A phase IIa study of the anti‐PD‐L1 antibody avelumab in relapsed/refractory PTCL: The AVAIL‐T trial

British Journal of Haematology, EarlyView.
The AVAIL‐T study, the first evaluation of programmed death ligand 1 (PD‐L1) blockade in relapsed/refractory peripheral T‐cell lymphomas (PTCL), demonstrated limited single agent activity with durable responses seen in a minority. Circulating tumour DNA revealed distinct mutational dynamics and mass cytometry identified perturbed T‐cell subsets ...
Matthew J. Ahearne, Matthew A. Timmins, Charlotte Gaskell, Aimee Jackson, Clare Morland, Sonia Fox, Louise Hopkins, Nadia Nawaz, Susann Lehmann, Marc Wadsley, Caroline Cowley, Jacqueline Shaw, Naeem Khan, Nagesh Kalakonda, Christopher Trethewey, Ram Malladi, Paul Fields, Dima El Sharkawi, Michael Quinn, Nimish Shah, Andrew Davies, Kim Linton, Pam McKay, Rod Johnson, Simon D. Wagner, David Lewis, Graham P. Collins, Christopher P. Fox, Kate Cwynarski   +28 more
wiley   +1 more source

Comparison of Intranasal Dexmedetomidine and Midazolam as Premedication in Children Undergoing Cardiac Surgeries and Procedures

Acta Medica Bulgarica
Aims and Objectives. To compare premedication with intranasal dexmedetomi-dine and intranasal midazolam for their sedative effects and ease of parental separation in children undergoing cardiac surgeries.
Arora P., Nayar P., Choudhury A., Kohli S., Savithri H.   +4 more
doaj   +1 more source

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source

Effects of propofol and thiopentone, and benzodiazepine premedication on heart rate variability measured by spectral analysis.

, 2016
We studied the effects of temazepam premedication and induction of anaesthesia with thiopentone or propofol on the heart rate power spectrum in 47 patients undergoing elective minor surgery.

core   +1 more source

Behaviour Support in Dentistry Core Outcomes (BeSiDe‐CO): A Core Outcome Set Development Study

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives To develop a Core Outcome Set suitable for adults and children for use in studies of Dental Behaviour Support (DBS) techniques, including non‐pharmacological DBS, sedation and General Anaesthesia research. Methods Two systematic reviews generated a preliminary list of candidate outcomes that were shared with Key Stakeholders (KSG ...
Caoimhin Mac Giolla Phadraig, Isabel C. Olegário, Shaelynn Hsu, Maryam Al Zayer, Aisyah Binti Ahmad Fisal, Alison Dougall, Gareth B. Kitchen, Henry F. Duncan, Sarah Baker, Sharat Pani, Sreekanth Kumar Mallineni, Mandy Daly, The BeSiDe COS Collaboration, Tracey Scott, Carolyn Akintola, Éilish Burke, Steve Moore, Barbara Vallo, Jacobo Posse Limerese, Karin Alexandra Van Nes, Maiken Bagger, Olive Healy, Andrew Geddis‐Regan   +22 more
wiley   +1 more source

Population characteristics and weighted univariate analysis of risk factors associated with premedication use.

, 2019
Population characteristics and weighted univariate analysis of risk factors associated with premedication use.
Xavier Durrmeyer (362299), Valérie Benhammou (6556049), Emilie Courtois (3819703), Elizabeth Walter-Nicolet (6577022), Christophe Milesi (6253283), Pierre Tourneux (6323573), Ricardo Carbajal (3819712), Pierre-Yves Ancel (334274), Alain Beuchée (4458766)   +8 more
core   +1 more source

Comparison of Oral Moxonidine versus Clonidine in Adults Undergoing General Anaesthesia: A Double-blinded Randomised Controlled Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Anxiolysis helps in reducing perioperative adverse events. Clonidine is an established anxiolytic premedication but Moxonidine with a similar mechanism, has not been explored for the same. Moxonidine is an imidazoline receptor agonist which
Shree Bakshi, Anirudha Dewri, Paramanand Maheshwari, Hm Ravikiran, D Gita Devi, Prateek Shukla   +5 more
doaj   +1 more source

Ectopic pregnancy in a horse

Equine Veterinary Education, EarlyView.
Summary An ectopic fetus was discovered in the abdominal cavity of a 21‐year‐old Haflinger mare, which was referred to an equine clinic because of colic symptoms. The mare had been inseminated 3 years previously and was confirmed pregnant at 90 days.
M. S. Swoboda, A. K. Rötting, H. Sieme, J. Sielhorst   +3 more
wiley   +1 more source

Newborns should be receiving premedication before elective intubation [PDF]

, 2014
BACKGROUND: Intubation is a common neonatal procedure. Premedication is accepted as a standard of care, but its use is not universal and wide variations exist in practice.
Joolay, Yaseen, Harrison, Michael Charles, Horn, Alan Richard, Raban, Moegammad Shukri   +3 more
core   +1 more source