Results 91 to 100 of about 28,510 (217)

The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid, Aiman Saleh A. Mohammed, Gábor Mohácsi, Benjámin Paskuj, Gergő Bitay, Jakub Tomek, Sahil Dalal, Tamás Árpádffy‐Lovas, Vivien Demeter‐Haludka, István Koncz, Muhammad Naveed, László Virág, Norbert Nagy, András Varró, István Baczkó, Norbert Jost, Zsófia Kohajda, Leila Topal   +17 more
wiley   +1 more source

Lidocaine Spray Versus Viscous Lidocaine Solution Plus Lidocaine Spray in Patients Undergoing Non‐Sedated Esophagogastroduodenoscopy: A Randomized Controlled Trial

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Background Non‐sedated esophagogastroduodenoscopy (EGD) is preferred in patients at risk from sedatives. However, achieving effective pharyngeal anesthesia remains a challenge. This study compared lidocaine spray alone with a combination of lidocaine spray and viscous lidocaine solution.
Natee Faknak, Anuch Singhattha, Thidarat Inpen, Papatsakorn Nopjaroonsri   +3 more
wiley   +1 more source

Patient‐Centric First‐in‐Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T‐Cell Engagers in Multiple Myeloma

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 745-752, September 2026.
The minimal anticipated biological effect level (MABEL) approach to first‐in‐human (FIH) dose calculation can lead to long dose‐escalation periods before observing clinical activity. We used a novel ex vivo MABEL approach to calculate the FIH starting dose for forimtamig, a T‐cell bispecific antibody under investigation for the treatment of relapsed ...
Thomas E. Kraft, Estelle Marrer‐Berger, Sara Belli, Helene Haegel, Anneliese Schneider, Anna Maria Giusti, Michael Bscheider, Wolfgang Jacob, Martin Weisser, Laura Blanco, Nicolas Frances, Eva Rossmann, Guido Steiner, Aintzane Zabaleta Azpiroz, Bruno Paiva, Ludovic Martinet, Tanja Fauti   +16 more
wiley   +1 more source

Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial

Drug Design, Development and Therapy
Longbin Zheng,1,* Tao Fang,2,* Wei Zhang,1 Xiaojing Zhang,1 Zhiqiang Ren,1 Weimin Qin,1 Wenbo Liang,1 Qing Ma,1 Ning Yin1 1Department of Anesthesiology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, People’s ...
Zheng L, Fang T, Zhang W, Zhang X, Ren Z, Qin W, Liang W, Ma Q, Yin N   +8 more
doaj  

Premedication Before Contrast-Enhanced Computed Tomography Scans: A Systematic Review

Scripta Score Scientific Medical Journal
Background: The use of iodinated contrast media (ICM) in Computed tomography (CT) scan improves visualization but carries a risk of hypersensitivity and other adverse reactions.
Maulana Muhtadin, Ihsan Fahmi Rofananda
doaj   +1 more source

PREMEDICATION [PDF]

BMJ, 1935
openaire   +2 more sources

Mass culture of equine synovial fluid‐derived mesenchymal stromal cells using nonwoven polyethylene terephthalate fabrics

Equine Veterinary Journal, Volume 58, Issue 5, Page 1454-1466, September 2026.
Abstract Background Culture protocols need to yield 100 million equine synovial fluid (SF)‐derived mesenchymal stromal cells (SF‐MSCs) in around 3 weeks are needed, before these cells can be evaluated as agents of articular repair in clinical trials. Objectives To investigate mass culture of equine SF‐MSC culture protocols using nonwoven polyethylene ...
Miho Daniel Yoshitomi, Tomohide Kuramoto, Takashi Hatazoe, Kenta Mitsuda, Henry Smith, Kazuhiro Misumi   +5 more
wiley   +1 more source

Evaluation of a Wearable Device for Cardiorespiratory Monitoring in Healthy Anaesthetised Cats

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
The OSS was evaluated for heart rate and peripheral oxygen saturation monitoring in healthy anaesthetised cats. A very strong correlation was observed between OSS and a veterinary reference monitor for heart rate measurements and peripheral oxygen saturation values were clinically equivalent within predefined equivalence limits.
Şule Melek, Ömer Tarık Orhun, Mümin Gökhan Şenocak, Taner Arslan   +3 more
wiley   +1 more source

PREMEDICATION [PDF]

BMJ, 1931
openaire   +2 more sources

Association Between Postoperative Pain and Inflammatory Biomarkers After Ovariohysterectomy in Dogs: A Pilot Study

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Elective ovariohysterectomy in dogs induced significant time‐dependent changes in postoperative pain scores and systemic inflammatory/stress biomarkers. However, these biomarkers did not reliably reflect acute pain intensity, supporting multimodal pain assessment rather than biomarker‐based evaluation alone.
Alper Yasin Çiplak, Şifanur Aydın, Damla Tuğçe Okur   +2 more
wiley   +1 more source