Results 51 to 60 of about 52,144 (318)

Premedication prior to PEG‐asparaginase is cost‐effective in pediatric patients with acute lymphoblastic leukemia

, 2021
BackgroundPEG‐asparaginase is critical in pediatric acute lymphoblastic leukemia (ALL) therapy but is highly immunogenic. Severe allergic reactions lead to substitution of further PEG‐asparaginase with Erwinia.
Meghan McCormick, Lapinski, Jillian, Erika Friehling, Smith, Kenneth, Jillian Lapinski, McCormick, Meghan, Kenneth Smith, Friehling, Erika   +7 more
core   +1 more source

Use of triazolam and alprazolam as premedication for general anesthesia [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundTriazolam has similar pharmacological properties as other benzodiazepines and is generally used as a sedative to treat insomnia. Alprazolam represents a possible alternative to midazolam for the premedication of surgical patients.
Doyun Kim, Seongheon Lee, Taehee Pyeon, Seongwook Jeong   +3 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation

Anesthesiology and Pain Medicine, 2019
Background Dental rehabilitation surgery is associated with significant fear and anxiety with subsequent psychological disturbances. Midazolam has been used frequently as a premedication. However, it may be associated with side effects.
Mohamed E Oriby
semanticscholar   +1 more source

Premedication In Anesthesia [PDF]

, 2015
Premedication In ...
rastak, shahram
core  

Subperiosteal peri‐implant augmented layer to correct bone dehiscence at immediate implant placement

Clinical Advances in Periodontics, EarlyView.
Abstract Background The purpose of the present case report is to describe the potential of the subperiosteal peri‐implant augmented layer (SPAL) technique in peri‐implant bone dehiscence (PIBD) correction at immediate implant placement (IIP). Methods This case report describes the application of the SPAL technique in two patients undergoing IIP at ...
Tommaso Grenzi, Chiara Franzini, Mattia Severi, Leonardo Trombelli   +3 more
wiley   +1 more source

General issues on premedication [PDF]

, 2010
Premedication refers to a drug treatment given to a patient before a medical procedure (surgical or invasive). Some groups of pharmacological substances are used as premedication: 1. hypnotics (barbiturates, benzodiazepines) 2.
Prodan, Irina
core  

Influence of the Residual Gensini Score on Prognosis of Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The residual Gensini score (rGS) was developed to quantify the severity of coronary atheroma burden after coronary revascularisation. The predictive value of the rGS for clinical outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) remains unexplored.
Batric Popovic, Nassima Djaballah, Mirela Tomic, Renaud Fay, Victorine Fraichot, Florian Eggenspieler, Pierre Adrien Metzdorf, Jeanne Varlot, Edoardo Camenzind   +8 more
wiley   +1 more source

Effect of oral melatonin on patients' anxiety scores and dose requirement of propofol during bispectral index-guided induction of general anesthesia

The Indian Anaesthetists' Forum, 2019
Background: Management of preoperative anxiety in surgical patients is usually required for better perioperative hemodynamics and patient management. Various pharmacological and nonpharmacological entities have been used for the management of anxiety ...
Nikhil Jain, Hemlata, Tanmay Tiwari, Monica Kohli, Girish Chandra, Vinod Kumar Bhatia   +5 more
doaj   +1 more source

Patient‐Centric First‐in‐Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T‐Cell Engagers in Multiple Myeloma

Clinical Pharmacology &Therapeutics, EarlyView.
The minimal anticipated biological effect level (MABEL) approach to first‐in‐human (FIH) dose calculation can lead to long dose‐escalation periods before observing clinical activity. We used a novel ex vivo MABEL approach to calculate the FIH starting dose for forimtamig, a T‐cell bispecific antibody under investigation for the treatment of relapsed ...
Thomas E. Kraft, Estelle Marrer‐Berger, Sara Belli, Helene Haegel, Anneliese Schneider, Anna Maria Giusti, Michael Bscheider, Wolfgang Jacob, Martin Weisser, Laura Blanco, Nicolas Frances, Eva Rossmann, Guido Steiner, Aintzane Zabaleta Azpiroz, Bruno Paiva, Ludovic Martinet, Tanja Fauti   +16 more
wiley   +1 more source