Results 121 to 130 of about 86,712 (254)

Clinical Relevance of the SOUND and INSEMA Trials in Women With Early Breast Cancer in Australia and New Zealand

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Axillary surgery in breast cancer has undergone progressive de‐escalation. The recent Sentinel Node versus Observation after Axillary Ultrasound (SOUND) and Intergroup Sentinel Mamma (INSEMA) trials have demonstrated that sentinel lymph node biopsy may be safely omitted in selected patients. This study aimed to evaluate the clinical
Matea Dominkovic, Kerry Hitos, Wei Wang, T. Michael Hughes, James French, Nicholas Ngui   +5 more
wiley   +1 more source

All‐cause mortality after self‐reported vs. hospital‐reported gynecological surgery: The HUNT study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Mortality risk after hysterectomy and oophorectomy varied between hospital‐reported and self‐reported exposure. This could explain the heterogeneity between previous studies. In this study, hospital‐reported hysterectomy and bilateral oophorectomy were not associated with increased mortality risk, but early bilateral oophorectomy was.
Tina Ellinor Rosland, Nora Johansen, Astrid Helene Liavaag, Bjørn Olav Åsvold, Are Hugo Pripp, Trond Melbye Michelsen   +5 more
wiley   +1 more source

Exploring endometrial cancer in premenopausal women—A nationwide PremEnCa cohort study

Acta Obstetricia et Gynecologica Scandinavica
Introduction An increased incidence of endometrial cancer has been noted, especially in premenopausal women in countries with rapid socioeconomic transition. In one of the largest patient cohorts of women ≤50 years, with manually validated register data,
Chrysanthos Ioannou, Cecilia Malmsten, Per Ehn, Erik Holmberg, Pernilla Dahm‐Kähler, Karin Stålberg   +5 more
doaj   +1 more source

Menopausal status at the age of 46: Its association with depressive and anxiety symptoms and morbidity in women—A northern Finland birth cohort 1966 study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Women who are perimenopausal or menopausal at age 46 have a higher risk of anxiety and depressive symptoms than premenopausal women. Early‐onset menopause highlights the need for mental health support during and after the menopausal transition. Abstract Introduction The incidence of several morbidities increases during the menopausal transition ...
Tiia Saarinen, Susanna M. Savukoski, Paula Pesonen, Jouko Miettunen, Maarit Niinimäki   +4 more
wiley   +1 more source

Incidental Findings From Treatment Response Monitoring in Oncological Care: Ethical Reflections

Bioethics, EarlyView.
ABSTRACT The question of how to handle incidental findings in medicine has attracted a lot of attention in the bioethics literature. The most widely discussed examples come from genetics (e.g., next generation sequencing) and medical imaging (e.g., neuroimaging).
Jasper Debrabander, Stefano Fanti, Elisabetta Lalumera   +2 more
wiley   +1 more source

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

British Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

Characteristics of Vaginal Microbiome in Women with Pelvic Inflammatory Disease in Korea [PDF]

Polish Journal of Microbiology, 2021
SUKYUNG KIM, HOONHEE SEO, MD ABDUR RAHIM, HANIEH TAJDOZIAN, YUN-SOOK KIM, HO-YEON SONG   +5 more
doaj   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source