Results 21 to 30 of about 86,712 (254)

Appraising Adjuvant Endocrine Therapy in Hormone Receptor Positive HER2-Negative Breast Cancer—A Literature Review

Current Oncology, 2022
Background: Approximately 75% of breast cancer (BC) is associated with luminal differentiation expressing endocrine receptors (ER). For ER+ HER2− tumors, adjuvant endocrine therapy (ET) is the cornerstone treatment.
Danilo Giffoni de Mello Morais Mata, Carlos Amir Carmona, Andrea Eisen, Maureen Trudeau   +3 more
doaj   +1 more source

Hyperprolactinaemia is common in Chinese premenopausal women with breast diseases

Frontiers in Genetics, 2023
Purpose: Hyperprolactinaemia has been proposed to play a role in breast lesions pathophysiology. Thus far, controversial results have been reported for the relationship between hyperprolactinaemia and breast lesions.
Jiang Zhu, Yuyi Tang, Yuyi Tang, Cuixia Lv, Han Cong, Jie Liu, Song Zhao, Yawen Wang, Kai Zhang, Wenbin Yu, Qian Cai, Qian Cai, Rong Ma, Jianli Wang   +13 more
doaj   +1 more source

Bone Health and Endocrine Therapy with Ovarian Function Suppression in Premenopausal Early Breast Cancer: A Real-Life Monocenter Experience with Denosumab

Current Oncology
Adjuvant endocrine therapy for early breast cancer significantly reduces recurrence but increases bone fragility. Given limited data on denosumab (60 mg every 6 months) in premenopausal patients receiving endocrine therapy for early breast cancer, we ...
Angelachiara Rotondi, Valentina Frescura, Giorgia Arcuri, Giovanna Garufi, Letizia Pontolillo, Luca Mastrantoni, Elena Di Monte, Noemi Maliziola, Maria Antonia Fucile, Francesca Salvatori, Rita Mondello, Ilaria Poli, Gaia Rachele Oliva, Ginevra Mongelli, Antonella Palazzo, Alessandra Fabi, Emilio Bria, Giampaolo Tortora, Armando Orlandi   +18 more
doaj   +1 more source

The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer

Frontiers in Oncology, 2021
This study aimed to evaluate and compare the effects of various endocrine therapies on lipid profiles in young patients with breast cancer. A retrospective, single-center study was performed to investigate the effects of tamoxifen (TAM), tamoxifen plus ...
Yi-Kun Kang, Xue Wang, Nan-Lin Hu, Jian Yue, Yi-Ran Si, Jie Ju, Song-Lin Gao, Peng Yuan   +7 more
doaj   +1 more source

CYP3A variation, premenopausal estrone levels, and breast cancer risk.

, 2012
BACKGROUND: Epidemiological studies have provided strong evidence for a role of endogenous sex steroids in the etiology of breast cancer. Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated
Gibson, Lorna J, Folkerd, Elizabeth, Hillier, Stephen G, Sawyer, Elinor, Ross, Gillian, Peto, Julian, Johnson, Nichola, Tomlinson, Ian P., Coupland, Ben, Fletcher, Olivia, Haynes, Ben, Kerin, Michael J, Williamson, Jill, Schoemaker, Minouk, Simpson, Gemma, Palles, Claire, Swerdlow, Anthony, Jones, Michael, Dos-Santos-Silva, Isabel, Dowsett, Mitch, Walker, Kate, Houlston, Richard S, Kerin, Michael, Zvelebil, Marketa, Gibson, Lorna J., Ashworth, Alan, Tomlinson, Ian P, Tomczyk, Katarzyna, Orr, Nick; id_orcid, Orr, Nick, Swerdlow, Anthony J, Houlston, Richard S., Dos Santos Silva, Isabel, Hillier, Stephen G., Broderick, Peter, Chilcott-Burns, Sarah, Walker-Springett, Kate   +36 more
core   +1 more source

Osteoporosis in premenopausal women

, 2018
Although osteoporosis is generally considered as a disease affecting essentially aged women after menopause, it can occur at any age, and it also affects occasionally premenopausal women.
Serge Rozenberg, Rozenberg, Serge
core   +1 more source

Adjuvant ovarian suppression in premenopausal breast cancer. [PDF]

, 2015
BACKGROUND Suppression of ovarian estrogen production reduces the recurrence of hormone-receptor-positive early breast cancer in premenopausal women, but its value when added to tamoxifen is uncertain.
Geyer, Charles E, Coates, Alan S., Coates, Alan S, H. R. Bonnefoi, Coleman, Robert, M. Colleoni, G. A. Da Prada, Davidson, Nancy E., Ingle, James N., Buchholz, Stefan, Price, Karen N, P. A. Francis, R. D. Gelber, Francis, Prudence A., K. N. Price, G. Viale, Láng, István, Colleoni, Marco, Francis, Prudence A, Burstein, Harold J., M. Rabaglio Poretti, Bonnefoi, Hervé R, Maibach, Rudolf, J. N. Ingle, A. Giobbie Hurder, Davidson, Nancy E, E. Ciruelos, Rabaglio-Poretti, Manuela, Viale, Giuseppe, M. Bellet, Geyer, Charles E., Ingle, James N, R. Maibach, Walley, Barbara A., Rabaglio, Manuela, Bellet, Meritxell, Kerbrat, Pierre, Martino, Silvana, B. Ruepp, B. A. Walley, A. S. Coates, Ciruelos, Eva, Price, Karen N., S. Buchholz, Winer, Eric P, Gelber, Richard D, Walley, Barbara A, Gelber, Richard D., Fleming, Gini F, M. A. Climent, Climent, Miguel A, S. Martino, Da Prada, Gian Antonio, Regan, Meredith M., C. E. Geyer, Burstein, Harold J, H. J. Burstein, Giobbie-Hurder, Anita, Goldhirsch, Aron, P. Kerbrat, Regan, Meredith M, N. E. Davidson, E. P. Winer, A. Goldhirsch, Winer, Eric P., M. M. Regan, Climent, Miguel A., G. F. Fleming, R. Coleman, Fleming, Gini F., Ruepp, Barbara, Bonnefoi, Hervé R., I. Láng   +72 more
core   +2 more sources

Hypertensive conditions of pregnancy, preterm birth, and premenopausal breast cancer risk: a premenopausal breast cancer collaborative group analysis [PDF]

, 2023
Purpose: Women with preeclampsia are more likely to deliver preterm. Reports of inverse associations between preeclampsia and breast cancer risk, and positive associations between preterm birth and breast cancer risk are difficult to reconcile.
Giles, G.G, House, M.G, Goldberg, M, Nichols, H.B, Jones, M.E, Swerdlow, A.J, Eliassen, A.H, Schoemaker, M.J, Yarosh, R, Mitra, S, Bertrand, K.A, O’Brien, K.M, Sandin, S, Willett, W.C, Yin, W, Milne, R.L, Palmer, J.R, Sandler, D.P   +17 more
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Management of a Borderline Brenner Tumor of the Ovary in a Premenopausal Woman in Northern Tanzania. A Rare Case Report and Review of the Current Literature

Clinical Case Reports
Brenner tumors are rare ovarian neoplasms that are typically small and unilateral. Most cases are benign; less than 5% of all Brenner tumors are borderline or proliferative.
John Lugata, Laetitia Makower, Ashley Rapheal, Yusuph Mwidibo, Bariki Mchome, Alex Mremi   +5 more
doaj   +1 more source