Results 121 to 130 of about 5,219,314 (384)

Reducing gastrointestinal anastomotic leak rates: Review of challenges and solutions [PDF]

, 2016
Various techniques and interventions have been developed in an effort to obviate gastrointestinal anastomotic leaks. This review is intended to delineate potential modifications that can be made to reduce the risk of anastomotic leaks following ...
Philllips, Benjamin
core   +4 more sources

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

Effectiveness of mandala coloring and playing with Lego on children’s preoperative anxiety: A Randomized Clinical Trial [PDF]

Journal of Research Development in Nursing and Midwifery
Background: Mandala Coloring and Playing are distraction strategies to reduce the anxiety level in children. However, their effects are inconsistent and have received little attention for the management and prevention of anxiety in hospitalized children.
Azam Shirinabadi Farahani, Ali Omidi, Reihane Moghimian Shahrbabaki, Fatemeh Akbari Arjestan, Mohammadamin Jandaghian-Bidgoli, Zohreh Makarem   +5 more
doaj  

A retrospective audit of factors contributing to delays in preoperative antibiotic administration: Arrival-to-incision time in Kuwait

Journal of Healthcare Administration
Background: Preoperative antibiotic administration within 60 minutes before surgical incision is a critical component of surgical site infection (SSI) prevention. Despite these guidelines, adherence to this protocol varies.
Ganesh Shinde, Zahraa Ismail
doaj   +1 more source

A Careful Preoperative Airway Assessment [PDF]

International Journal of Clinical & Medical Imaging, 2017
Clinical Image: A 45-year-old male subject with recent diagnosis of right colon cancer was referred to Department of Otorhinolaryngology for a preoperative airway assessment. The patient presented a long years history of intermittent hoarseness, retrosternal burning and rare episodes of laryngospasm, which however have never been further investigated ...
openaire   +1 more source

Senescence‐Inducing Therapy Sequential NIR‐II Mild Photothermal/Senolytic Therapy of Triple Negative Breast Cancer

Advanced Science, EarlyView.
Targeting triple‐negative breast cancer remains challenging due to limited therapies and drug resistance. A sequential theranostic strategy combining palbociclib‐induced senescence (enhancing heat sensitivity via HSP70 downregulation) with an NIR‐II nanoplatform (IQ NPs) for mild photothermal therapy (PTT) and quercetin‐mediated senolysis is developed.
Liya Yu, Yehui Kang, Mengdie Yu, Yuejia Ding, Yang Chen, Qingyuan Wu, Yu Cai, Huiyu Liu, Zhenye Lv   +8 more
wiley   +1 more source

Preoperative oral health care reduces postoperative inflammation and complications in oral cancer patients.

Experimental and Therapeutic Medicine, 2016
The records of 70 patients with oral cancer who were treated at a single institution between 2008 and 2014 were reviewed. The body temperature, white blood cell count, and C-reactive protein (CRP) levels were compared between those who had received ...
H. Shigeishi, K. Ohta, S. Fujimoto, T. Nakagawa, K. Mizuta, Shigehiro Ono, H. Shimasue, Yoshiaki Ninomiya, K. Higashikawa, Misato Tada, F. Ishida, Gaku Okui, Toshiya Okumura, A. Fukui, Kazumi Kubozono, Kazuhiro Yamamoto, Y. Ishida, Sayaka Seino, Miho Hashikata, K. Sasaki, T. Naruse, M. Z. Rahman, Ryo Uetsuki, Akiko Nimiya, Megumi Takamoto, Kana Dainobu, Tomoko Tokikazu, H. Nishi, M. Sugiyama, M. Takechi   +29 more
semanticscholar   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pan   +4 more
wiley   +1 more source

Management of hospital admission, patient information and education, and immediate preoperative care. [PDF]

Saudi J Anaesth, 2023
Greco M, Calgaro G, Cecconi M.
europepmc   +1 more source