Role of the Preoptic Area in Sleep and Thermoregulation. [PDF]
Front Neurosci, 2021 Sleep and body temperature are tightly interconnected in mammals: warming up our body helps to fall asleep and the body temperature in turn drops while falling asleep. The preoptic area of the hypothalamus (POA) serves as an essential brain region to coordinate sleep and body temperature.
Rothhaas R, Chung S.
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Lateral preoptic area neurons signal cocaine self-administration behaviors. [PDF]
Eur J Neurosci, 2021 Abstract The lateral preoptic area is implicated in numerous aspects of substance use disorder. In particular, the lateral preoptic area is highly sensitive to the pharmacological properties of psychomotor stimulants, and its activity promotes drug‐seeking in the face of punishment and reinstatement during abstinence.
Coffey KR, Venkat V, West MO, Barker DJ.
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Macroscale connections of the mouse lateral preoptic area and anterior lateral hypothalamic area. [PDF]
J Comp Neurol, 2022 AbstractThe macroscale neuronal connections of the lateral preoptic area (LPO) and the caudally adjacent lateral hypothalamic area anterior region (LHAa) were investigated in mice by anterograde and retrograde axonal tracing. Both hypothalamic regions are highly and diversely connected, with connections to >200 gray matter regions spanning the ...
Hahn JD +5 more
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Correction for Pickett et al., Microglia phagocytosis mediates the volume and function of the rat sexually dimorphic nucleus of the preoptic area. [PDF]
Proc Natl Acad Sci U S A, 2023 europepmc +3 more sources
Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice. [PDF]
Nat CommunWu K +7 more
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Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states. [PDF]
ElifeCao Z, Yung WH, Ke Y.
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Astrocytes in the Ventrolateral Preoptic Area Promote Sleep [PDF]
The Journal of Neuroscience, 2020 Although ventrolateral preoptic (VLPO) nucleus is regarded as a center for sleep promotion, the exact mechanisms underlying the sleep regulation are unknown. Here, we used optogenetic tools to identify the key roles of VLPO astrocytes in sleep promotion.
Jae-Hong Kim +5 more
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Glucoregulatory responses to hypothalamic preoptic area cooling [PDF]
Brain Research, 2019 Normal glucose homeostasis depends on the capacity of pancreatic β-cells to adjust insulin secretion in response to a change of tissue insulin sensitivity. In cold environments, for example, the dramatic increase of insulin sensitivity required to ensure a sufficient supply of glucose to thermogenic tissues is offset by a proportionate reduction of ...
Kenjiro, Muta +6 more
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Dopamine Activates Noradrenergic Receptors in the Preoptic Area [PDF]
The Journal of Neuroscience, 2002 Dopamine (DA) facilitates male sexual behavior and modulates aromatase activity in the quail preoptic area (POA). Aromatase neurons in the POA receive dopaminergic inputs, but the anatomical substrate that mediates the behavioral and endocrine effects of DA is poorly understood.
Cornil, Charlotte +4 more
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Recovery of Sleep Atter Fetal Preoptic Transplantation in Medial Preoptic Area-lesioned Rats [PDF]
Sleep, 1998 Changes in sleep after fetal preoptic (POA) tissue transplantation were studied in rats which had been made insomniac by a medial preoptic area (mPOA) lesion. Two days after the N-methyl D-aspartic acid (NMDA) lesion of the mPOA, fetal POA tissues (obtained from 14- to 17-day-old fetuses) were transplanted into the lesioned mPOA.
J, John, V M, Kumar, G, Gopinath
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