Results 61 to 70 of about 9,766,304 (314)

Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis. [PDF]

, 2017
In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the ...
Barakat, Rita, Brooks, George A, Efe, Gizem, Garan, Steven A, Gouw, Arvin M, Mehdizadeh, Morvarid, Preecha, Andrew   +6 more
core   +1 more source

Recovery of Sleep Atter Fetal Preoptic Transplantation in Medial Preoptic Area-lesioned Rats [PDF]

Sleep, 1998
Changes in sleep after fetal preoptic (POA) tissue transplantation were studied in rats which had been made insomniac by a medial preoptic area (mPOA) lesion. Two days after the N-methyl D-aspartic acid (NMDA) lesion of the mPOA, fetal POA tissues (obtained from 14- to 17-day-old fetuses) were transplanted into the lesioned mPOA.
Gomathy Gopinath, Velayudhan Mohan Kumar, Joshi John   +2 more
openaire   +3 more sources

Hormonal gain control of a medial preoptic area social reward circuit

Nature Neuroscience, 2017
Neural networks that control reproduction must integrate social and hormonal signals, tune motivation, and coordinate social interactions. However, the neural circuit mechanisms for these processes remain unresolved.
J. McHenry, James M. Otis, Mark A. Rossi, J. Robinson, O. Kosyk, Noah W. Miller, Zoé A. McElligott, E. Budygin, E. Budygin, E. Budygin, D. Rubinow, G. Stuber   +11 more
semanticscholar   +1 more source

CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice

eLife, 2023
Evidence suggests that estradiol-sensing preoptic area GABA neurons are involved in the preovulatory surge mechanism necessary for ovulation. In vivo CRISPR-Cas9 editing was used to achieve a 60–70% knockdown in estrogen receptor alpha (ESR1) expression ...
Jenny Clarkson, Siew Hoong Yip, Robert Porteous, Alexia Kauff, Alison K Heather, Allan E Herbison   +5 more
doaj   +1 more source

Optogenetic mapping of feeding and self-stimulation within the lateral hypothalamus of the rat. [PDF]

PLoS ONE, 2020
The lateral hypothalamus (LH) includes several anatomical subregions involved in eating and reward motivation. This study explored localization of function across different LH subregions in controlling food intake stimulated by optogenetic ...
Kevin R Urstadt, Kent C Berridge
doaj   +1 more source

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons

Journal of Neuroscience, 2018
The hypothalamus plays an important role in the regulation of sleep/wakefulness states. While the ventrolateral preoptic nucleus (VLPO) plays a critical role in the initiation and maintenance of sleep, the lateral posterior part of the hypothalamus ...
Yuki C. Saito, T. Maejima, Mitsuhiro Nishitani, Emi Hasegawa, Y. Yanagawa, Michihiro Mieda, T. Sakurai   +6 more
semanticscholar   +1 more source

Opposing actions of co-released GABA and neurotensin on the activity of preoptic neurons and on body temperature

eLife
Neurotensin (Nts) is a neuropeptide acting as a neuromodulator in the brain. Pharmacological studies have identified Nts as a potent hypothermic agent.
Iustin V Tabarean
doaj   +1 more source

Neurobiology of Maternal Behavior in Nonhuman Mammals: Acceptance, Recognition, Motivation, and Rejection

Animals, 2022
Among the different species of mammals, the expression of maternal behavior varies considerably, although the end points of nurturance and protection are the same. Females may display passive or active responses of acceptance, recognition, rejection/fear,
Genaro A. Coria-Avila, Deissy Herrera-Covarrubias, Luis I. García, Rebeca Toledo, María Elena Hernández, Pedro Paredes-Ramos, Aleph A. Corona-Morales, Jorge Manzo   +7 more
doaj   +1 more source

AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building

Journal of Neuroscience, 2018
AGRP (agouti-related neuropeptide) expressing inhibitory neurons sense caloric needs of an animal to coordinate homeostatic feeding. Recent evidence suggests that AGRP neurons also suppress competing actions and motivations to mediate adaptive behavioral
Xing-Yu Li, Ying Han, Wen Zhang, Shao-Ran Wang, Yi-Chao Wei, Shuai-shuai Li, Jun-kai Lin, Jing-Jing Yan, Ai-Xiao Chen, Xin Zhang, Zheng-Dong Zhao, Wei L. Shen, Xiao-hong Xu   +12 more
semanticscholar   +1 more source

Serotonin and motherhood: From molecules to mood [PDF]

, 2019
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming, Lonstein, Joseph S., Pawluski, Jodi L.   +2 more
core   +2 more sources