Results 231 to 240 of about 647,081 (351)

Oral PrEP use among pregnant or parenting young women in South Africa: evidence from a large community-based implementation study. [PDF]

BMC Public Health
Chen-Charles J, Davey DJ, Rousseau E, Little F, Toska E, Mathola N, Macdonald P, Vanto O, Wallace M, Bekker LG.   +9 more
europepmc   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Rome Victorious. The Irresistible Rise of the Roman Empire (D.) Hoyos, Pp. xvi + 256, maps, b/w pls. London: Bloomsbury Academic, 2023 (first published 2019). Paper, £14.99 (Cased, £35). ISBN: 9781780762753.

The Journal of Classics Teaching
Brian J. Zawiski
doaj   +1 more source

Population characteristics, PrEP eligibility, and trust in family planning providers among women accessing public family planning clinics in Kenya. [PDF]

PLOS Glob Public Health
Mukasa D, Kinuthia J, Matemo D, Morton J, Wandera C, Ukah UV, Mugwanya KK, FP Plus Project Team.   +7 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Warrior of Rome: Falling Sky (H.) Sidebottom, Pp. 376, map. London: Zaffre, 2022. Cased, £16.99. ISBN: 978-1838778019

The Journal of Classics Teaching
Brian J. Zawiski
doaj   +1 more source

HIV pre-exposure prophylaxis practices in Florida, USA: Clinicians' perceptions of initiation, risk identification, barriers, and facilitators. [PDF]

PLoS One
Siddiqi KA, Canidate SS, Liu Y, Kriegel LS, Monjur S, Cook C, Cook RL.   +6 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Diversity and the Study of Antiquity in Higher Education. Perspectives from North America and Europe (D.) Libatique and (F.) McHardy (edd.), Pp. viii + 144. Abingdon, Oxon: Routledge, 2023. Cased, £48.99. ISBN: 978-1-032-23512-7

The Journal of Classics Teaching
Brian J. Zawiski
doaj   +1 more source