Results 121 to 130 of about 8,738,312 (332)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Improving University Principal Preparation Programs: Five Themes From The Field [PDF]

open access: yes, 2016
What is the state of university-based principal preparation programs? How are these essential training grounds of future school leaders viewed -- by themselves as well as by the school districts that hire their graduates? Do the programs need to improve?
Jacquelyn Davis
core  

Water Footprint Assessment of Agricultural Crop Productions in the Dry Farming Region, Shanxi Province, Northern China

open access: yesAgronomy
Exploring the crop production water footprint and their driving factors is of significant importance for management of agricultural water resources.
Lu Wang   +3 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Preparation of organic hydrazides [PDF]

open access: yes, 1959
Thesis (M.A.)--Boston UniversityDue to the actual high price of hydrazine, this chemical cannot be used in an economical preparation of organic hydrazides. A synthesis of such hydrazides can be envisaged by the reduction of N-nitroamides.
Amiel, Jean-Pierre L.
core   +1 more source

Evaluation and preparation of the poor-risk patient with cancer for major surgery [PDF]

open access: bronze, 1954
John S. LaDue, Felix Wróblewski
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Distinctive physiological and molecular responses of foxtail millet and maize to nicosulfuron

open access: yesFrontiers in Plant Science
IntroductionNicosulfuron is the leading acetolactate synthase inhibitor herbicide product, and widely used to control gramineous weeds. Here, we investigated the metabolic process of nicosulfuron into foxtail millet and maize, in order to clarify the ...
Boyu Lu   +11 more
doaj   +1 more source

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