Results 161 to 170 of about 4,526,308 (312)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2009 EXECUTIVE SUMMARYThis project report will discuss the findings of a baseline/scoping exercise ofthe National Approach to Mentor Preparation for Nurses and Midwives (CoreCurriculum Framework) (NES 2007) to six mentor preparation programmes inScotland. The
Donaldson, Jayne H +4 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Alternative Preparation Techniques in the Treatment of Dental Caries
, 2006 The author gives the preview of various preparation techniques except of the rotary preparation. Preparation techniques include mechanical, chemomechanical, kinetic and hydrokinetic preparation.
L. Roubalíková
core
Effect of Different Specimen Preparation Methods on Dentin Shear Bond Strength: Polyethylene Tubes vs Jig System. [PDF]
J Adhes DentBalaban Karakaş S +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Sol-gel preparation of silicon nitride materials
, 2009 Sol-gel techniques are mainly used for oxides but are of growing interest for non-oxide materials. They allow formation of solid materials through gelation of precursor solutions and can be used to control composition and to produce a large number of ...
Hassan, Shereen Hassan Mohamed Gaber
core
Adequate Colon Preparation in Screening Colonoscopy
Colorectal cancer (CRC) is one of the most common forms of cancer worldwide, being the fourth most prevalent cancer and the third most common in terms of mortality.
Elena CONSTANTIN +2 more
core +1 more source