Results 31 to 40 of about 197,265 (305)

Considerations for bioanalytical characterization and batch release of COVID-19 vaccines

npj Vaccines, 2021
The COVID-19 pandemic has prompted hundreds of laboratories around the world to employ traditional as well as novel technologies to develop vaccines against SARS-CoV-2. The hallmarks of a successful vaccine are safety and efficacy.
Gautam Sanyal, Anna Särnefält, Arun Kumar   +2 more
doaj   +1 more source

UK emergency preparedness: a holistic local response?

, 2008
Purpose – This paper aims to argue that to address the consequences of climate change and variability a greater focus on pre-emergency planning that engages a wider stakeholder group must be adopted.
O'Brien, Geoff
core   +1 more source

Supporting Survivor‐Centered Care Through Digital Health Integration

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak, Rebecca Williamson‐Lewis, Michael O'Connor, Michael Palgon, Yu‐Ra Kim, Michael Schuckenbrock, Paula Edwards, Abraham Mendoza, Anthony Adams, Brian Arriaga‐Solis, Justin Parker, Harry Tinoco‐Giraldo, Jason King, C. Michael Fordis, Karen E. Effinger, Maria Monica Gramatges   +15 more
wiley   +1 more source

Optical microscopy reveals the dynamic nature of B. pseudomallei morphology during β-lactam antimicrobial susceptibility testing

BMC Microbiology, 2020
Background In Gram-negative species, β-lactam antibiotics target penicillin binding proteins (PBPs) resulting in morphological alterations of bacterial cells.
Heather P. McLaughlin, Julia Bugrysheva, David Sue   +2 more
doaj   +1 more source

Strategies for supplying face masks to the population of Taiwan during the COVID-19 pandemic

BMC Public Health, 2021
Background The use of face masks has become ubiquitous in Taiwan during the early COVID-19 pandemic. A name-based rationing system was established to enable the population of Taiwan to purchase face masks.
Chin-Mei Liu, Charles Tzu-Chi Lee, Shu-Mei Chou, Hai-Yun Ko, Jen-Hsin Wang, Yi-Chien Chih, Chia-Chi Chang   +6 more
doaj   +1 more source

A step towards reinvigorating the COVID-19 response: an intra-action review of the WHO Regional Office for Africa Incident Management Support Team

BMJ Global Health, 2023
The WHO Regional Office for Africa (AFRO) COVID-19 Incident Management Support Team (IMST) was first established on 21 January 2020 to coordinate the response to the pandemic in line with the Emergency Response Framework and has undergone three ...
Thierno Balde, Roland Kimbi Wango, Joseph Okeibunor, Abdou Salam Gueye, Boniface Oyugi, Ebenezer Obi Daniel, Hillary Njenge, Pierre Ongolo Zogo, Helena O’Malley, Etien Luc Koua, Adama Thiam, Dick Chamla, Fiona Braka   +12 more
doaj   +1 more source

Epistemic preparedness

BMJ Global Health
Preparedness strategies for emergent infectious diseases have focused on microbial surveillance, medical stockpiling and healthcare infrastructure resilience. But what does it mean to be epistemically or cognitively prepared for the next disease outbreak?
Anderson, Warwick, Lancaster, Kari, van Wichelen, Sonja, Abimbola, Seye, Ankeny, Rachel, Engelmann, Lukas, Fearnley, Lyle, Giles-Vernick, Tamara, Hegarty, Benjamin, Jephcott, Freya, Ludovice, Nicolo, Roitman, Janet, Steere-Williams, Jacob, Stoove, Mark, Viaña, John Noel, Waldby, Catherine, Yang, Rachel   +16 more
openaire   +6 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

Microorganisms, 2021
Marek’s disease (MD), caused by MD herpesvirus (MDV), is an economically important disease in chickens. The efficacy of the existing vaccines against evolving virulent stains may become limited and necessitates the development of novel antiviral ...
Arjun Challagulla, Kristie A. Jenkins, Terri E. O’Neil, Shunning Shi, Kirsten R. Morris, Terry G. Wise, Prasad N. Paradkar, Mark L. Tizard, Timothy J. Doran, Karel A. Schat   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source