Results 51 to 60 of about 292,616 (315)

iSIMPATHY: a multinational pre–post non-randomised intervention study transforming medication review

BMJ Open
Background Taking multiple medicines can be appropriate but has the potential to be problematic. The Implementing Stimulating Innovation in the Management of Polypharmacy and Adherence THrough the Years (iSIMPATHY) project used the 7-Steps person-centred
Michael G Scott, Ciara Kirke, Glenda Fleming, Alpana Mair, Claire Scullin, Nils Micheal, Stuart Law, Yousaf Kanan, Joanne Brown, Nadia H Skinner, Deborah Kyle   +10 more
doaj   +1 more source

A Global Survey on Opioid Stewardship Practices in Hospitals: A Cross-Sectional Pilot Study

Pharmacy, 2021
Objective: The objectives of this study are to describe opioid stewardship practices in hospitals being implemented globally, in addition to investigating the attitudes and perceptions of health professionals regarding opioid stewardship in the hospital ...
Sarah Al-Samawy, Nisha Varughese, Regis Vaillancourt, Xiao Yu (William) Wang, Jonathan Penm   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Prescribing errors : what’s the story? [PDF]

, 2001
Although prescribing errors are one of the most common causes of preventable iatrogenic injury, there have been relatively few studies of their incidence and causes. The majority of the studies that have been carried out have been based in secondary care.
Dean, Bryony
core  

Can authorities appreciably enhance the prescribing of oral generic risperidone to conserve resources? : findings from across Europe and their implications [PDF]

, 2014
Generic atypical antipsychotic drugs offer health authorities opportunities for considerable savings. However, schizophrenia and bipolar disorders are complex diseases that require tailored treatments.
Barbui, Corrado, Bennie, Marion (Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde), Simoens, Steven, Bucsics, Anna (Department of Finance, Faculty of Business, Economics and Statistics, University of Vienna), Andrew Martin, Martin, Andrew (NHS Greater Manchester Commissioning Support Unit, Salford), Finlayson, Alexander E, Finlayson, Alexander E (Department of Primary Care Sciences, Oxford University), Piessnegger, Jutta (Hauptverband der Österreichischen Sozialversicherungsträger), Kathleen Bennett, Barbui, Corrado (WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona), Zara, Corinne, Corrado Barbui, Marion Bennie, Brian Godman, Alexander E Finlayson, Godman, Brian, Steven Simoens, Raschi, Emanuel, Anna Bucsics, Martin, Andrew, Raschi, Emanuel (Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna), Bennett, Kathleen, Petzold, Max (Centre for Applied Biostatistics, Occupational and Environmental Medicine, University of Gothenburg), Petzold, Max, Piessnegger, Jutta, Marie Persson, Max Petzold, Jutta Piessnegger, Emanuel Raschi, Bennett, Kathleen (Department of Pharmacology & Therapeutics, Trinity Centre for Health Sciences, St James Hospital), Persson, Marie, Godman, Brian (Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge), Zara, Corinne (Barcelona Health Region, Catalan Health Service), Persson, Marie (Unit of Medicine Support, Public Healthcare Services Committee, Stockholm County Council), Corinne Zara, Bennie, Marion, Simoens, Steven (Department of Pharmaceutical, and Pharmacological Sciences, KU Leuven), Bucsics, Anna   +38 more
core   +1 more source

The Use of Off-Label Medications in Newborn Infants Despite an Approved Alternative Being Available—Results of a National Survey

Pharmacy, 2022
Neonates continue to be treated with off-label or unlicensed drugs while in hospital. However, some medications that have previously been used in adults underwent clinical testing and licensure for use with a different indication in the neonatal and ...
Alex Veldman, Eva Richter, Christian Hacker, Doris Fischer   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Knowledge, Attitudes and Perceptions of Medical Students on Antimicrobial Stewardship

Antibiotics, 2020
Antimicrobial Resistance (AMR) is an ongoing threat to modern medicine throughout the world. The World Health Organisation has emphasized the importance of adequate and effective training of medical students in wise prescribing of antibiotics Furthermore,
Panagiotis Efthymiou, Despoina Gkentzi, Gabriel Dimitriou   +2 more
doaj   +1 more source

Impact of the COVID-19 Pandemic on the Prescribing Patterns of First-Line Antibiotics in English Primary Care: A Longitudinal Analysis of National Prescribing Dataset

Antibiotics, 2021
The COVID-19 pandemic has impacted on public access to health services. This study aimed to investigate the impact of COVID-19 pandemic on commonly prescribed first-line antibiotics in English primary care.
Alisha Zubair Hussain, Vibhu Paudyal, Muhammad Abdul Hadi   +2 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source