Results 81 to 90 of about 28,302 (250)

A Pharmacogenomics‐Guided Antihypertensive Strategy for Blood Pressure Reduction in Rural China: A Cluster‐Randomized Controlled Trial

Health Care Science, EarlyView.
This manuscript reports the findings from the Pharmacogenomic‐guided Antihypertensive Strategy Trial study amidst the deteriorating blood pressure control observed globally during the COVID‐19 pandemic. A pharmacogenomics‐guided strategy achieved a 98.4% blood pressure control rate at 4 weeks in rural China.
Wangjun Qin, Mengke Yu, Ying Zhu, Queran Lin, Limei Yin, Guisheng Liu, Yaping Wang, Guangqiang Lu, Xiaofei Liu, Pengmei Li, Xudong Kong, Li Zhao, Kun Tang, Jiangli Jin, Yu Xiong, Yingnan Zhao, Yan Yan, Bo Li, Azeem Majeed, Xianbo Zuo, Yue Qiu, Jiantuo Yu, Lihong Liu   +22 more
wiley   +1 more source

Pain severity and opioid use in patients with spine-related diagnoses

Frontiers in Pain Research
ObjectiveClinical guidelines recommend opioid use only in severe and unresponsive cases of low back pain. Limited evidence exists on pain levels and opioid use in spine-related diagnoses (SRD).
Chijioke M. Okeke, Chijioke M. Okeke, Javeria Khalid, J. Douglas Thornton, J. Douglas Thornton, Rajender R. Aparasu, Rajender R. Aparasu   +6 more
doaj   +1 more source

Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Postoperative radiotherapy is the standard treatment for locally advanced oral squamous cell carcinoma (OSCC); however, the indication for neck irradiation (NI) in pN0 patients remains debatable. We evaluated whether the omission of NI compromises outcomes in pT3–T4 pN0 patients treated with adequate neck dissection (ND).
Mathilde Mirallié, Anouchka Modesto, Marie Pajiep, Sébastien Vergez, Jérôme Sarini, Lucie Piram, Céline Dalmasso, Benjamin Vairel, Emilien Chabrillac, Agnès Dupret‐Bories   +9 more
wiley   +1 more source

Interpretation of Key Updates in the 36th Edition of Clinical and Laboratory Standards Institute M100 Standard

iLABMED, EarlyView.
ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley   +1 more source

Microbiome‐mediated plant‐soil feedbacks as a tool for resilient agriculture

iMetaOmics, EarlyView.
Translating plant‐soil feedbacks (PSFs) into reliable agricultural management requires shifting from input‐dependent practices toward endogenous, process‐driven crop resilience. To bridge this gap, we propose a predictive framework centered on three strategic interventions: engineering the crop holobiont, diversifying the soil habitat, and deploying ...
Muhammad Asif, Hazrat Bilal, Min Xiao, Lei Dong, Wen‐Jun Li   +4 more
wiley   +1 more source

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Evaluating the feasibility of implementing a prescription drug misuse prevention intervention in the community: a mixed methods study. [PDF]

BMC Public Health, 2023
Al Rawwad T, Tata V, Wanat MA, Campbell D, Thornton D.   +4 more
europepmc   +1 more source

“Back to the Future”: Testing the “Individual Problems and Strengths” Scale With a Stepwise Confirmatory Factor Analysis Approach

Journal of Clinical Psychology, EarlyView.
ABSTRACT Routine Outcome Monitoring systems have been developed to monitor how clients' lives change over the course of therapy. However, for such systems to be effective, they must possess sufficient construct validity and scale‐reliability to warrant their use. In this study, using a sample of 841 Norwegian clients, we performed the first independent
Rune Zahl‐Olsen, Nicolay Gausel, Åshild Tellefsen Håland, Terje Tilden   +3 more
wiley   +1 more source

Effort-Reward Imbalance at Work and Prescription Drug Misuse-Prospective Evidence from Germany. [PDF]

Int J Environ Res Public Health, 2022
Sattler S, von dem Knesebeck O.
europepmc   +1 more source

The Psychometric Properties and Clinical Usefulness of the Difficulties in Emotion Regulation Scale in Forensic Settings

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objective The Difficulties in Emotion Regulation Scale (DERS) is a widely used measure of emotion dysregulation across clinical contexts. However, its psychometric properties and clinical utility have not been thoroughly examined in forensic populations.
Adam Meddeb, Märta Wallinius, Johan Berlin, Natalie Laporte, Malin Hildebrand Karlén, Claudia Mazzeschi, Elisa Delvecchio, Patrizia Velotti, Carlo Garofalo   +8 more
wiley   +1 more source