Results 111 to 120 of about 190,228,706 (268)

Meaning in life in cancer patients: relationships with illness perception and global meaning changes [PDF]

, 2018
Background Meaning in life seems to play an important role at various stages of coping in cancer patients. It can influence the ways in which cancer patients perceive their illness and potential changes in beliefs and goals.
Krok, Dariusz, Telka, Ewa
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Meaning in Life and Psychological Weil-Being in Spanish Emerging Adults

Acta Colombiana de Psicología
Experiencing meaning in life (MiL) and psychological well-being (PWB) is an important developmental task in emerging adulthood, perhaps more than in any other period in life due to its transitional character and to the nature of its features, in Western ...
Joaquín García-Alandete, Eva Rosa Martínez, Pilar Sellés Nohales, Beatriz Soucase Lozano   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The mediating effect of meaning in life in the relationship between self-compassion and psychopathological symptoms among Chinese adults

Discover Psychology
Background While there is consistent evidence linking self-compassion to depression and anxiety, the specific pathways that connect them remain poorly understood. One potential pathway is the presence of meaning in life.
Tsz Wah Ma
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Relationship between Presence of Meaning, Search for Meaning, and Subjective Well-Being: A Three-Level Meta-Analysis based on the Meaning in Life Questionnaire

, 2019
Meaning in life can be understood as how much people experience life meaning, i.e., presence of meaning (POM) and how intensely they seek life meaning, i.e., search for meaning (SFM). Previous research has related POM and SFM to the subjective well-being (SWB) of individuals, but the findings are inconsistent.
Dou, Kai, Bin Li , Jian
openaire   +2 more sources

Growth mindset and learning engagement among Chinese college students: a chain mediation model and gender difference

BMC Psychology
The present study explored the mechanism growth mindset influences learning engagement among Chinese College Students, through the chain mediating roles of searching for meaning, presence of meaning and satisfaction with life, and the moderating role of ...
Yaping Pan, Mingjie Huang, Jingxuan Lou
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source