Results 111 to 120 of about 46,260,578 (335)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

THE PRESENT CONDITION OF SCIENCE IN THE HIGH SCHOOL [PDF]

, 1911
Ada L. Weckel
openalex   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Cows, Bandits, and Violent Conflicts: Understanding Cattle Rustling in Northern Nigeria

Africa Spectrum, 2016
Cattle rustlings have become a major crime in Nigeria recently, with the northern region being the hardest hit. In the past few years, rustling activities have resulted in the theft of a huge number of cows, deaths of people and destruction of property ...
Azeez Olaniyan, Aliyu Yahaya
doaj  

The present status of vestibular tests in intracranial conditions [PDF]

, 1925
Lewis Fisher
openalex   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Making Migrants Responsible for Development: Cape Verdean Returnees and Northern Migration Policies Wenn Migranten für Entwicklung verantwortlich gemacht werden: Rückkehrer nach Kap Verde und vom „Norden“ geprägte Migrationspolitik

Africa Spectrum, 2011
In recent years, there has been a surge of “Northern” policy documents concerned with increasing the positive effects of international migration in countries of origin.
Lisa Åkesson
doaj  

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

From Quibbles to Substance: A Response to Responses Vom Streit zur Substanz: Eine Antwort auf die Antworten

Africa Spectrum, 2013
Contribution to the Debate on Anthropology in Africa in Africa Spectrum.Beitrag zur "Debate on Anthropology in Africa" in Africa Spectrum.
Francis B. Nyamnjoh
doaj