Results 141 to 150 of about 19,830,962 (273)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Lifetime Prevalence of Nonsuicidal Self-Injury in Adolescents: Reliability of a Dichotomous Survey Item. [PDF]

Int J Methods Psychiatr Res
Aspeqvist E, Andersson H, Dahlström Ö, Korhonen L, Zetterqvist M.   +4 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

On the Conservativeness of Robust Variance Estimators in Propensity Score Weighted Cox Models. [PDF]

Pharm Stat
Morita H, Orihara S, Shimizu F, Taguri M.   +3 more
europepmc   +1 more source

Stochastic approximations of present value functions. [PDF]

The aim of the paper is to apply the method proposed by Denuit, Genest and Marceau (1999) for deriving stochastic upper and lower bounds on the present value of a sequence of cash flows, where the discounting is performed under a given stochastic return ...
Denuit, M, Marceau, E, Cossette, H, Dhaene, Jan   +3 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Chiasmatic Present

Teksty Drugie
This article advocates the usefulness of the research categories and proposals presented in Rebeca Bryant and Daniel M. Knight’s book The Anthropology of the Future (2019), in describing the challenges and threats we face in the future.
Marek Zaleski
doaj  

The Present.

, 1968
Mode of access: Internet.Edited by W. H. Channing.Reprint.

core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Environmental volatility is associated with adaptive caution in visual search. [PDF]

PLoS Comput Biol
Qiu N, Allenmark F, Chen S, Müller HJ, Shi Z.   +4 more
europepmc   +1 more source