Results 121 to 130 of about 3,827,941 (337)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Seed multispectral imaging combined with machine learning algorithms for distinguishing different varieties of lettuce (Lactuca sativa L.)

Food Chemistry: X
Accurate identification of high-quality seeds is crucial for maintaining superior crop traits. Lettuce is widely consumed vegetable with diverse varieties, however, the traditionally identification methods are both time-consuming and labor-intensive ...
Jinpeng Wei, Zhangyan Dai, Qi Zhang, Le Yang, Zhaoqi Zeng, Yuliang Zhou, Jun Liu, Bingxian Chen   +7 more
doaj   +1 more source

Articular cartilage repair & joint preservation: A review of the current status of biological approach.

Journal of Clinical Orthopaedics and Trauma, 2021
K. Solanki, S. Shanmugasundaram, Neha D Shetty, Seok-Jung Kim   +3 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Pretreatment with nano-silver extends the post-harvest longevity of gladiolus cut flowers by reducing free water mobility

Horticultural Plant Journal
The water content of cut flowers is a significant factor in their post-harvest quality. In this study, we examine the efficacy of silver nanoparticles (NS) on the longevity of cut gladiolus, with a focus on water state and distribution. We used Low-field
Xiumei Li, Qinjian Liu, Hongbo Li, Yuanyuan Chen, Zhongjian Chen, Shenggen He, Jun Liu, Shijuan Yan   +7 more
doaj   +1 more source

Novel Biomarkers Associated With Progression and Prognosis of Bladder Cancer Identified by Co-expression Analysis

Frontiers in Oncology, 2019
Our study's goal was to screen novel biomarkers that could accurately predict the progression and prognosis of bladder cancer (BC). Firstly, we used the Gene Expression Omnibus (GEO) dataset GSE37815 to screen differentially expressed genes (DEGs ...
Yejinpeng Wang, Liang Chen, Lingao Ju, Lingao Ju, Lingao Ju, Kaiyu Qian, Kaiyu Qian, Kaiyu Qian, Xuefeng Liu, Xinghuan Wang, Xinghuan Wang, Yu Xiao, Yu Xiao, Yu Xiao, Yu Xiao, Yu Xiao   +15 more
doaj   +1 more source

Strengthening and Preserving Family is Essential to America\u27s Future [PDF]

, 2011
This editorial provides an overview of how the articles in this issue contextualize the wide-range of perceptions and practices that support (and sometimes undermine) family strengths.
Flores, William B.
core   +1 more source

Long-term preservation effects on biological properties of acellular placental sponge patches.

Materials Science and Engineering C: Materials for Biological Applications, 2021
Fatemeh Asgari, Sadjad Khosravimelal, M. Koruji, Zahra Aliakbar Ahovan, A. Shirani, A. Hashemi, Hatef Ghasemi Hamidabadi, N. Chauhan, L. Moroni, R. Reis, S. Kundu, M. Gholipourmalekabadi   +11 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source