Results 151 to 160 of about 3,722,975 (358)

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

Journal of the American College of Cardiology, 2017
Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials. A greater understanding of the in vivo human processes involved, and in particular, which are the causes and which ...
Lewis, Gavin, Schelbert, Erik B, Williams, Simon G, Cunnington, Colin, Ahmed, Fozia, McDonagh, Theresa, Miller, Christopher   +6 more
openaire   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Biologically Plausible Brain Graph Transformer [PDF]

arXiv
State-of-the-art brain graph analysis methods fail to fully encode the small-world architecture of brain graphs (accompanied by the presence of hubs and functional modules), and therefore lack biological plausibility to some extent. This limitation hinders their ability to accurately represent the brain's structural and functional properties, thereby ...
arxiv  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Structure-guided discovery of novel AflG inhibitors for aflatoxin contamination control in aspergillus flavus

Frontiers in Microbiology
Aflatoxins (AFs) are highly carcinogenic metabolites produced by Aspergillus species that can contaminate critical food staples, leading to significant health and economic risks.
Fenghua Wang, Fenghua Wang, Weijie Zhou, Maohua Yang, Jinlu Niu, Wenjie Huang, Zhaofu Chen, Yuanyuan Chen, Dongdong Wang, Jun Zhang, Shaowen Wu, Shijuan Yan   +11 more
doaj   +1 more source

Of Mice and Machines: A Comparison of Learning Between Real World Mice and RL Agents [PDF]

arXiv
Recent advances in reinforcement learning (RL) have demonstrated impressive capabilities in complex decision-making tasks. This progress raises a natural question: how do these artificial systems compare to biological agents, which have been shaped by millions of years of evolution?
arxiv  

Quantum Simulation of Phylogenetic Trees [PDF]

arXiv, 2011
Quantum simulations constructing probability tensors of biological multi-taxa in phylogenetic trees are proposed, in terms of positive trace preserving maps, describing evolving systems of quantum walks with multiple walkers. Basic phylogenetic models applying on trees of various topologies are simulated following appropriate decoherent quantum ...
arxiv  

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Wheat Embryo Albumin and Its Peptide Alleviate Acute Exercise Fatigue as Energy Supplement

Foods
Wheat embryo albumin (WEA), rich in amino acids with a good balanced proportion, demonstrates plentiful biological activities. The effects of WEA and its peptide with the best antioxidant ability (F3) as a post-workout and pre-workout energy supplement ...
Aimei Liao, Xiaoxiao Li, Yanbing Wang, Zhirui Ding, Long Pan, Yinchen Hou, Quanping Liu, Jianzheng Li, Menghui Shang, Jihong Huang   +9 more
doaj   +1 more source

Non-local kinetic and macroscopic models for self-organised animal aggregations [PDF]

arXiv, 2014
The last two decades have seen a surge in kinetic and macroscopic models derived to investigate the multi-scale aspects of self-organised biological aggregations. Because the individual-level details incorporated into the kinetic models (e.g., individual speeds and turning rates) make them somewhat difficult to investigate, one is interested in ...
arxiv