Results 231 to 240 of about 3,199,743 (304)

From prediction to actionable mechanisms: Explainable multi‑omics AI for farm‑to‑fork postharvest preservation. [PDF]

Imeta
Ma P, Jia X, Fan B, Li B, Lin T, Sheng J, Wei CI, Lu Y, Ma Y, Chen L, Jiu S, Wang F.   +11 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Molecular effects of ovarian stimulation for fertility preservation in breast cancer: a paired-biopsy analysis. [PDF]

ESMO Open
Barral El Gaoui Y, Brasó-Maristany F, Borrás Capó A, Casals G, Agustí I, Altinier G, Chic Ruche N, Galván P, Ganau S, González-Farre B, Salvador C, Peon S, Méndez M, Vidal M, Prat A, Manau Trullás D.   +15 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

<i>Ligusticum chuanxiong</i> CO₂ Oil as a Natural Antimicrobial Agent for Postharvest Preservation of Fresh White Radish: <i>In Vitro</i>, <i>In Situ</i> and Storage Evaluation. [PDF]

Foods
Kačániová M, Yu Y, Qiao M, Ban Z, Li L, Cunkun C, Garzoli S, Bianchi A.   +7 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Tumor-metabolism integrated therapy: A new paradigm for fertility-sparing treatment in endometrial cancer. [PDF]

Chin J Cancer Res
Xing T, Wang J.
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Esthetic Reconstruction of Severe Vertical Soft Tissue Deficiency in the Lateral Incisor Region. [PDF]

Clin Case Rep
Habash G, Thikrallah A, Kamal MS, Jayash SN.   +3 more
europepmc   +1 more source

Radiographic Documentation of Implant-Supported Rehabilitation Following Endodontic Failure of a Mandibular First Molar: A Case Report. [PDF]

Cureus
Mejia Ocampo EM, Mora V, Romero M, Perez Quevedo M, De la Roche IC.   +4 more
europepmc   +1 more source