Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
Advanced Functional Materials, EarlyView.This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson +12 more
wiley +1 more source
Advances in abiotic tissue-based biomaterials: A focus on decellularization and devitalization techniques. [PDF]
Mater Today BioTavares DF, Mano JF, Oliveira MB.
europepmc +1 more source
Advanced Functional Materials, EarlyView.A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee +12 more
wiley +1 more source
Recent Advances in the Applications and Studies of Polysaccharide-, Protein-, and Lipid-Based Delivery Systems in Enhancing the Bioavailability of Capsaicin-A Review. [PDF]
Polymers (Basel)Qiu X, Xie J, Mei J.
europepmc +1 more source
Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth
Advanced Functional Materials, EarlyView.Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung +8 more
wiley +1 more source
Fertility preservation: is there a model for gender-dysphoric youth? [PDF]
Front Endocrinol (Lausanne)Laidlaw MK, Lahl J, Thompson A.
europepmc +1 more source
Advanced Functional Materials, EarlyView.Ambient‐dried composite aerogels integrating MOF‐303, TEMPO‐oxidized cellulose nanofibers (TOCNF), and hygroscopic salts enable high‐performance atmospheric water harvesting (AWH), achieving competitive uptake at both low and high humidity. Enhanced with a solar‐evaporation layer, these scalable aerogels support self‐sustained plant growth in a ...
Ahmadreza Ghaffarkhah +12 more
wiley +1 more source
Metabolomics reveals the effect of vacuum packaging combined with moderate-temperature preservation on quality changes of tender ginger. [PDF]
Food Chem XJing YY +5 more
europepmc +1 more source
Advanced Functional Materials, EarlyView.The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar +6 more
wiley +1 more source
Planned oocyte cryopreservation in Hong Kong: a potential prototype for mainland China. [PDF]
Sex Reprod Health MattersNgan OM, Ng EH, Yue Y, Li RH.
europepmc +1 more source