Results 91 to 100 of about 1,061,857 (308)

Sharing Social Research Data in Ireland: A Practical Tool [PDF]

open access: yes, 2016
Your data is valuable and has an importance outside your own original project. Allowing other researchers to reuse your data maximises the impact of your work, and benefits both the scholarly community and society in general.
Brid McGrath, Robin Hanan
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Economic evaluation of LIFE methodology [PDF]

open access: yes, 2007
Background: The LIFE project (Lifecycle Information For E-Literature) was carried out during 2004-2006 by a consortium consisting of The British Library and University College London Library Services .
Björk, B.-C.
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Patrimoniul arhitectural industrial romanesc – trecut şi prezent [PDF]

open access: yesUrbanism. Arhitectura. Constructii, 2012
The development of industrial activities on the Romanian territory is experiencing a considerable seniority, generating as a result an industrial heritage that stands out through its versatility (history, technology, architecture and esthetic).
Daniela Stoian   +2 more
doaj  

Preserving Film Preservation in the Digital Era [PDF]

open access: yes, 2013
This paper explores the current controversies surrounding film preservation in the digital era. Questions address the benefits of new technologies and the potential sacrifices to a film\u27s authenticity and designation as a valued historical, social ...
Bastron, Becca
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

STELLAR (Semantic Technologies Enhancing the Lifecycle of Learning Resources): Jisc Final Report [PDF]

open access: yes, 2013
[Project Summary] As one of the earliest distance learning providers The Open University (OU) has a rich heritage of archived learning materials. An ever increasing amount of that is in digital form and is being deposited with the University Archive ...
Brown, Sarah, Nurse, Richard
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Effects of four packaging materials on preservation of passion flower (Passiflora caerulea L.) fruit

open access: yesShipin yu jixie
Objective: The preservation effects of four packaging materials on passion fruit were studied. Methods: The fruit of passion flower cv. Huangjin (maturity: eight) was used as the research material, and passion flower fruit was treated via polyvinyl ...
LIN Yuzhao   +5 more
doaj   +1 more source

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