Results 81 to 90 of about 1,029,283 (311)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Privacy Preserving Recommender Systems
International Journal For Multidisciplinary ResearchPrivacy-preserving recommender systems are a growing area of research and development due to concerns about user privacy in digital environments. This review paper examines the existing methodologies and techniques used in designing and implementing these systems, focusing on their application in e-commerce, social media, and personalized content ...
Akash Sharma - +2 more
openaire +2 more sources
Location Privacy and Energy Preservation in Sensor Allocation Systems
International Journal of Distributed Sensor Networks, 2012 We propose sensor-to-task assignments algorithms that take into account location privacy issues. Our solutions enable the network to choose the “best” assignment of the available sensors to the tasks to maximize the utility of the network while ...
Hosam Rowaihy
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Heart transplant advances: Ex vivo organ-preservation systems. [PDF]
JTCVS Open, 2021 Bryner BS, Schroder JN, Milano CA.
europepmc +1 more source
Energy-preserving methods for Poisson systems
Journal of Computational and Applied Mathematics, 2012 The authors are concerned with initial value problems attached to systems of ordinary differential equations for which the vector field can be formulated in gradient form. For such problems they introduce and analyze a class of one-step methods which are energy-preserving and are also able to preserve quadratic Casimirs. A numerical test is carried out
BRUGNANO, LUIGI +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Maximum preservation of ecological systems in urban development
АрхитектонThe article presents an attempt to reveal the existence of certain urban-ecological trends as specified subjects of research. The study and practical application of these areas ensures the most complete preservation of existing ecological systems with ...
Lytkin Kuzma A.
doaj +1 more source
Leonardo da Vinci's "Last Supper": a case study to evaluate the influence of visitors on the Museum preservation systems. [PDF]
Environ Sci Pollut Res Int, 2022 Motta O +7 more
europepmc +1 more source
, 2005 These notes derive a number of technical results on nonlinear contraction theory, a comparatively recent tool for system stability analysis. In particular, they provide new results on the preservation of contraction through system combinations, a ...
Slotine, Jean-Jacques, Tabareau, Nicolas
core +3 more sources