Results 61 to 70 of about 12,292,407 (304)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Metals, 2022 The deformation behavior and the constitutive description of materials are important in the design and numerical simulation of manufacturing processes.
Maria Emanuela Palmieri, Luigi Tricarico
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
High-temperature deformation behavior and constitutive relationship of press-hardening steel 38MnB5
工程科学学报, 2019 With the rapid development of global economy, problems in energy production and environmental protection are becoming severe, and the automotive industry is under increasing pressure to reduce the weight of vehicles and improve crash performance.
LIN Li +4 more
doaj +1 more source
Cailiao gongcheng, 2020 The ultrafine-grained Mg-3Al-Zn alloy was prepared by high energy ball milling,cold vacuum press and warm extrusion. The influence of ball milling time on the microstructure and mechanical properties of the alloy was studied. The results show that Al and
FANG Wa, LI Ji-guang, DU Zheng-yong
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
RESEARCH ON INCREASING ACTIVE LIFE OF CUTTING TOOLS [PDF]
Fiabilitate şi Durabilitate, 2012 At the exploitation of dies the defections that occur, due mainly to non operating rules of exploration, the improperly conditions of the machine (press) in terms of cinematic precision and the wearing elements in relative motion (ram displacement ...
Alin STĂNCIOIU, Florin-Cristian CIOFU
doaj
Experimental Evaluation of Galling Under Press Hardening Conditions [PDF]
Tribology Letters, 2018 Severe adhesion, also referred to as galling, is a critical problem in press hardening, especially in stamping tools used for hot forming of Al–Si-coated ultra-high strength steel.
Liang Deng +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source