Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu+11 more
wiley +1 more source
Concern for the patient’s experience comes of age
In this special guest editorial for the inaugural issue of Patient Experience Journal. Dr. Press reflects on how the focus on patient experience has evolved. He starts with a reflection, "A journal devoted exclusively to the patient’s experience?
Irwin Press
doaj
Data-driven Approach to Measuring the Level of Press Freedom Using Media Attention Diversity from Unfiltered News [PDF]
Published by Reporters Without Borders every year, the Press Freedom Index (PFI) reflects the fear and tension in the newsroom pushed by the government and private sectors. While the PFI is invaluable in monitoring media environments worldwide, the current survey-based method has inherent limitations to updates in terms of cost and time.
arxiv
Roman Britain: and Ancient History at Oxford - The Romanization of Roman Britain, by F. Haverfield. Oxford: Clarendon Press, 1912. Pp. 68. 16 plates and drawings and 6 plans. 3s. 6d. net. - The Study of Ancient History at Oxford. By F. Haverfield. Oxford: Henry Frowde, 1912. Pp. 31. 1s. net. [PDF]
G. L. C.
openalex +1 more source
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu+12 more
wiley +1 more source
Calorimetric evidence for enhancement of homogeneity in high performance Sr1-xKxFe2As2 superconductors [PDF]
We comparatively studied the critical current density, magnetization and specific heat of the rolled and the hot-pressed Sr1-xKxFe2As2 tapes. The Schottky anomaly that is obvious in the specific heat of the rolled tape disappears in the hot-pressed tape.
arxiv
CARDIOVASCULAR EFFECTS OF SOME COMMONLY USED PRESSOR AMINES [PDF]
Domingo M. Aviado
openalex +1 more source
The Garden of Eden theorem: old and new [PDF]
We review topics in the theory of cellular automata and dynamical systems that are related to the Moore-Myhill Garden of Eden theorem.
arxiv
Frederick G. Detweiler, The Negro Press in the United States [PDF]
Frederick G. Detweiler
openalex +1 more source
Changing the Game: Women at Work in Las Vegas, 1940-1990, Joanne Goodwin University of Nevada Press Global Patents: Limits of Transnational Enforcement, Marketa Trimble Oxford University Press Neuropsychological Aspects of Substance Use Disorders ...
Levitan, Corey
core