Results 101 to 110 of about 468,087 (314)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 1965 Pontiac Press newspaper scanned from microfilmU.S. road toll sets mark for 3-day Fourth, reports push fatality total to record 542 ; Senate opens debate on bill for health care ; Man is killed after slaying 2 ; Combined force hunts Cong ; Hearing today ...
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 1965 Pontiac Press newspaper scanned from microfilmAirborne unit arrives in Viet ; B52 bombers hit suspected Cong position ; Says poverty funds lure agency staffers ; Sales, profits up at Chrysler ; Traffic light to be installed at troublesome intersection ...
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 1969 Pontiac Press newspaper scanned from microfilm3rd in command at PGH says he plans to resign in wake of 2 dismissals ; Outside panel to mull probe ; House approves pay deductions at surtax rate ; 3 Midwest cities rocked by violence ; Housing for aged pact
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 1965 Pontiac Press newspaper scanned from microfilmPontiac airport faces 5-year deficit, audit indicates ; U Thant's peace try fails ; Betsy left over billion in damages ; $1 million damage by Midwest storms ; OU fund bill is blocked by Senate GOP ; Says ...
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
, 1967 Pontiac Press newspaper scanned from microfilmBone find ages man by 800,000 years ; 7 NY arrests tied to alleged dope network ; GOP hopes to block proposed tax boost ; Two killed in separate accidents ; Nine in family killed by fire ; Study and plan for ...
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