Results 91 to 100 of about 468,087 (314)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Pontiac Press: 1969-04-26

open access: yes, 1969
Pontiac Press newspaper scanned from microfilmAerial near-miss reports soaring ; 213 Reds killed in attack, U.S. hits Cambodia sites ; School-aid victory looms for Milliken ; De Gaulle's job on line Sunday ; China demands Indian troops leave key pass ...

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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

The Pontiac Press: 1965-09-24

open access: yes, 1965
Pontiac Press newspaper scanned from microfilmJury continues deliberations in murder trial ; U.S., Panama agree to write new treaty ; Gromyko to U.S.: leave Viet ; Break wall (not ground) ; Four grants okayed for OU studies ; TV actress fights for life ;

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Sensorimotor Oscillations During a Reciprocal Touch Paradigm With a Human or Robot Partner

open access: yesFrontiers in Psychology, 2018
Robots provide an opportunity to extend research on the cognitive, perceptual, and neural processes involved in social interaction. This study examined how sensorimotor oscillatory electroencephalogram (EEG) activity can be influenced by the perceived ...
Nathan J. Smyk   +2 more
doaj   +1 more source

COMPARISON OF THE OPERATIONAL RELIABILITY OF THE PRESS-FIT CONNECTION AXLEBOX SITE, DIFFERENT METHODS RENEWED

open access: yesScience and Transport Progress, 2007
The articie describes results of operational tests of the joints with guaranteed tension of the axle-box of rail rolling stock, the inside surface of inner racers of which was restored by electrolytic galvanizing on pulse-reverse currents operation. A comparative analysis has been performed of the wear of surfaces of immobile joint parts, whose racers ...
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

The Pontiac Press: 1968-08-01

open access: yes, 1968
Pontiac Press newspaper scanned from microfilmAmericans responding to plight of starving Biafrans ; Missing Dem likely to stay on ballot ; Big steel's price boosts will stand despite LBJ ; Romney, Nixon tell Viet views ; Senators shelve Fortas decision ;

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Using the implementation research logic model to examine high-intensity resistance rehabilitation implementation in skilled nursing facilities: a mixed methods multi-site case study

open access: yesImplementation Science Communications
Background Implementing evidence-based rehabilitation in skilled nursing facilities (SNFs) is essential for enhancing physical function outcomes and mitigating risk of adverse events.
Lauren A. Hinrichs-Kinney   +5 more
doaj   +1 more source

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