Results 141 to 150 of about 2,044,415 (316)

Evaluation of Efficiency Improvement Potential Applying Proportional Pressure Control for Variable Speed Pumps in Water Supply

open access: yes
The proportional pressure control of centrifugal pumps may significantly increase the efficiency of water supply systems in terms of both electrical energy consumption and water leakage.
Dzelzītis, Egīls   +1 more
core  

PRESSURE CONTROL CHARACTERIZATION IN PRESSURIZATION SMOKE CONTROL SYSTEMS

open access: yesJournal of Architecture and Planning (Transactions of AIJ), 1998
Isao KASAHARA   +3 more
openaire   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Increased pain sensitivity in low blood pressure. [PDF]

open access: yes, 2008
. There is broad evidence for a functional interaction between the cardiovascular and pain regulatory systems. One result of this interaction is the reduced sensitivity to acute pain in individuals with elevated blood pressure, which has been established
Duschek, Stefan   +5 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Application of Feed Forward Fuzzy Immune Algorithm to Pressure Loop Control of Pump and Valve Combined EHA

open access: yes工程科学与技术, 2010
:Aiming at the specificity of pump-valve coordinated control electro-hydraulic actuator (EHA) that valve control loop response higher than pressure loop, the feed-forward fuzzy immune (FFIM) control strategy was applied to the pressure loop control.
Chen Hui   +3 more
doaj  

Optimizing blood pressure control through the use of fixed combinations

open access: yes, 2010
Rainer DüsingMedizinische Klinik und Poliklinik 1, Bonn, GermanyAbstract: The majority of hypertensive patients need ≥2 antihypertensive agents to reach goal blood pressure.
Rainer Düsing
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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