Results 121 to 130 of about 2,044,415 (316)

Towards Implementation of Max-Pressure Signal Timing on Minnesota Roads

, 2022
Max-pressure control is a new adaptive method for signal timing that is mathematically proven to achieve maximum throughput for the entire city road network.
Kang, Di, Barman, Simanta, Hu, Jeffrey, Odell, Michael, Levin, Michael W., Robbennolt, Jake   +5 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Twisted and Coiled Artificial Muscle-Based Dynamic Fixing System for Wearable Robotics Applications

Actuators
Wearable robotic devices for rehabilitation and assistive applications face a critical challenge: discomfort induced by prolonged pressure at the human–robot interface.
Simone Leone, Salvatore Garofalo, Chiara Morano, Michele Perrelli, Luigi Bruno, Giuseppe Carbone   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PSO‐SMADRC for altitude test facility intake pressure environmental simulation system

Electronics Letters
To address significant disturbances, including sudden air flow variation, model uncertainty, and unavoidable measurement noises during aeroengine transient tests in the intake environmental pressure simulation system (IEPSS), a sliding mode active ...
Li Chuanjian, Zhai Chao, Zhang Hehong, Zheng Shiqi   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Speed–Pressure Compound Control of Thrust System Based on the Adaptive Sliding Mode Control Strategy

The thrust system, an important subsystem of a tunnel boring machine (TBM), primarily provides thrust force and adjusts TBM’s attitude in real time. In the tunneling process, only controlling the thrust speed causes pressure oscillations, increases
Hong Liu, Tong Xing, Guofang Gong, Huayong Yang, Zhe Zheng, Dong Han, Lianhui Jia, Lijie Jiang   +7 more
core   +1 more source

Application of neural networks to automatic soil pressure balance control for shield tunneling

, 1997
In this paper, a shield control system software to balance soil pressure on the shield cutting face is described. This software, which adjusts the speed of the shield jack and the speed of the screw conveyor, is based on a neural network.
I. Yeh, I-Cheng Yeh
core   +1 more source