Results 111 to 120 of about 2,044,415 (316)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Intelligent pressure-controlled percutaneous unroofing: advancing minimally invasive renal cyst treatment

Frontiers in Medicine
ObjectiveSimple renal cysts (SRC) are common benign lesions that may require surgical intervention when symptomatic. This study aimed to compare the efficacy and safety of intelligent pressure-controlled percutaneous unroofing of renal cysts (IPC-PURC ...
Haijun Liao, Qiliang Zhai, Xin Huang, Chuance Du, Difu Fan, Yadong Li, Leming Song   +6 more
doaj   +1 more source

Online hose calibration for pressure control in mechanical ventilation

, 2019
Respiratory modules are used to assist patients who are unable to breathe sufficiently on their own. The aim of this paper is to develop a control method that achieves exact tracking of a time-varying target pressure, invariant to patient-hose-leak ...
Hunnekens, Bram, Bram Hunnekens, Heck, Frank, Joey Reinders, Nathan van de Wouw, Oomen, TAE Tom, Hunnekens, BGB Bram, Reinders, JMF, Tom Oomen, van de Wouw, Nathan, Oomen, Tom, Wouw, N Nathan van de, Frank Heck, Reinders, Joey   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

PLC-Based Pressure Control in Multi-Pump Applications

Electrical, Control and Communication Engineering, 2015
The paper is devoted to the centrifugal pumps represented the most popular type of pumping equipment used in different areas. The pressure control approach for variable speed driven (VSD) parallel connected centrifugal pumps is reported.
Vodovozov Valery, Raud Zoja, Gevorkov Levon   +2 more
doaj   +1 more source

Pressure-driven batch distillation optimal control for acetone-methanol separation

Over the last fifteen years, immense progress has been made in the research of pressure-swing batch distillation. The challenge lies in the fact that certain pressure-sensitive azeotropic mixtures cannot be separated in a regular open batch mode, with an
Marija, Stojkovic
core   +1 more source

Analysis and control of resonant cavity flows [PDF]

, 2013
Recently, the trend for the internalisation of stores within an aircraft fuselage has led to a renewed interest in the field of cavity aero-acoustics.
Roberts, David
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source