Results 101 to 110 of about 2,044,415 (316)

Precision grinding of cemented carbide ball valves by resin diamond wheels with different pore-forming agents

Jin'gangshi yu moliao moju gongcheng
To improve the machining effect of cemented carbide ball valves, pore-forming agents were introduced into resin diamond wheels. The mechanical properties, microstructures, and grinding performances of the wheels were analyzed, and the effects of hollow ...
Yanxin ZHU, Feng ZHAO
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Experimental Verification of a Two-Motor-Two-Pump Motor-Controlled Hydraulic Cylinder with Throttle-Free Passive Load-Holding Capability in Four-Quadrant Operations

Actuators
Among various motor-controlled hydraulic cylinder (MCC) topologies, the two-motor-two-pump (2M2P) MCC distinguishes itself through several notable advantages, including precise cylinder pressure control and eliminating mode switch oscillations ...
Wei Zhao, Morten Kjeld Ebbesen, Michael Rygaard Hansen, Torben Ole Andersen   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pressure Control for a Hydraulic Cylinder Based on a Self-Tuning PID Controller Optimized by a Hybrid Optimization Algorithm

Algorithms, 2017
In order to improve the performance of the hydraulic support electro-hydraulic control system test platform, a self-tuning proportion integration differentiation (PID) controller is proposed to imitate the actual pressure of the hydraulic support.
Ru Wang, Chao Tan, Jing Xu, Zhongbin Wang, Jingfei Jin, Yiqiao Man   +5 more
doaj   +1 more source

Perioperative Blood Pressure Control in Pheochromocytoma: The Role of Intravenous Urapidil

Pheochromocytomas are rare tumors derived from chromaffin cells of neural crest origin in the adrenal medulla. These neoplasms typically synthesize and secrete catecholamines. Excessive secretion of catecholamines can lead to severe and potentially fatal
Levent Özsarı, Egemen Tural
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Fuzzy-Type Fast Terminal Sliding-Mode Controller for Pressure Control of Pilot Solenoid Valve in Automatic Transmission

IEEE Access, 2019
The performance of the pilot solenoid valve (PSV) has a significant impact on the efficiency and service life of an automatic transmission (AT) in automobiles, and it is very difficult to achieve a perfect pressure tracking performance due to the ...
Xiangwen Fan, Yongyi He, Pengfei Cheng, Minglun Fang   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A feasibility study of solar radiation pressure feedback control strategy for unstable periodic orbits in the restricted three-body problem

, 2014
This paper investigates a Hamiltonian structure preserving control strategy that uses, where possible, solar radiation pressure as an alternative propellant-free control acceleration.
Colombo, Camilla, Soldini, Stefania, Walker, Scott J.I.   +2 more
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