Results 81 to 90 of about 24,188,873 (354)

Essential role of Kir5.1 channels in renal salt handling and blood pressure control.

JCI Insight, 2017
Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly rectifying K+ channels Kir4.1 (Kcnj10) and Kir5.1 (Kcnj16) are highly expressed in the basolateral membrane of distal renal tubules and contribute to Na+ reabsorption ...
O. Palygin, V. Levchenko, D. Ilatovskaya, T. Pavlov, O. Pochynyuk, H. Jacob, A. Geurts, M. Hodges, A. Staruschenko   +8 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multi-Valve Coordinated Disturbance Rejection Control for an Intake Pressure System Using External Penalty Functions

Actuators
Altitude test facilities for aero-engines employ multi-chamber, multi-valve intake systems that require effective decoupling and strong disturbance rejection during transient tests.
Louyue Zhang, Duoqi Shi, Chao Zhai, Zhihong Dan, Hehong Zhang, Xi Wang, Gaoxi Xiao   +6 more
doaj   +1 more source

OPTIMIZED CONTROLLER DESIGN FOR A BLOWDOWN SUPERSONIC WIND TUNNEL BY USING GENETIC ALGORITHM [PDF]

مجله مدل سازی در مهندسی, 2017
Blowdown Supersonic Wind Tunnels (SWTs) are generally operated with a constant stagnation pressure in the settling chamber, with control usually provided by one or more pressure regulators or control valves. In this paper, first, a Simulink block diagram
Mehradad Bazazzadeh, mojtabah Dehghan Manshadi, amin nazarian shahrbabaki, ali shahriari   +3 more
doaj   +1 more source

Uniaxial pressure control of competing orders in a high-temperature superconductor

Science, 2018
Squeezing into the third dimension Cuprate superconductors are known to harbor charge order in part of their phase diagram. Curiously, the order has a two-dimensional (2D) character at zero magnetic field, whereas a 3D order appears at high fields.
Hyun-Taek Kim, S. Souliou, M. Barber, E. Lefrançois, E. Lefrançois, M. Minola, M. Tortora, R. Heid, Nabhanila Nandi, R. Borzi, G. Garbarino, A. Bosak, J. Porras, T. Loew, M. König, P. Moll, A. P. Mackenzie, A. P. Mackenzie, B. Keimer, C. Hicks, M. Tacon   +20 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Pressure Acquisition System for In Vitro Mitral Valve Analysis [PDF]

, 2018
In vitro testing of the mitral valve chordae tendineae is utilized to aid in the understanding of the stresses that occur in vivo and improve upon surgical solutions that exist for mitral valve repair.
Peck, Laura
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Pressure Control in the Pump-Controlled Hydraulic Die Cushion Pressure-Building Phase Using Enhanced Model Predictive Control with Extended State Observer-Genetic Algorithm Optimization

Actuators
With the enhancement of safety performance requirements in the car manufacturing field, the quality standards for the sheet molding process have imposed higher demands.
Zhikui Dong, Song He, Yi Liao, Heng Wang, Mingxing Song, Jinpei Jiang, Gexin Chen   +6 more
doaj   +1 more source

Blood pressure control in type 2 diabetic patients

Cardiovascular Diabetology, 2017
Diabetes mellitus (DM) and essential hypertension are common conditions that are frequently present together. Both are considered risk factors for cardiovascular disease and microvascular complications and therefore treatment of both conditions is ...
A. Grossman, E. Grossman
semanticscholar   +1 more source