Results 141 to 150 of about 373,369 (294)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Mathematical Model for Prediction of Pressure Fluctuations in Common Rail

IEEE Access
This paper is based on fluid dynamics principle and analyzes the generation mechanism of pressure fluctuations in common rail (CR). We have derived a hyperbolic partial differential equation (HPDE) to describe pressure fluctuations in CR based on mass ...
Yun Bai, Chengda Du, Qiang Sun, Chao Yang, Simin Lan   +4 more
doaj   +1 more source

The Complexity of Blood Pressure Fluctuation Mediated the Effects of Hypertension on Walking Speed in Older Adults. [PDF]

Front Aging Neurosci, 2021
Jiang X, Cai Y, Zhao Y, Gao X, Peng D, Zhang H, Deng W, Fu W, Qin N, Chang R, Manor B, Zhou J.   +11 more
europepmc   +1 more source

An experimental study of the properties of surface pressure fluctuations in strong adverse pressure gradient turbulent boundary layers [PDF]

Experimental data were obtained on blade self-noise generation by strong adverse-pressure-gradient attached boundary layers and by separated turbulent boundary layers that accompany stall.
Simpson, R. L.
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Intraocular pressure fluctuation following intravitreal dexamethasone implant and incidence of secondary ocular hypertension: a Zambian perspective. [PDF]

Pan Afr Med J, 2021
Raj P, Kumar K, Balasubramaniam S, Geetha CS, Agarwal A.   +4 more
europepmc   +1 more source

Fluctuation spectra in the NASA Lewis bumpy-torus plasma [PDF]

The electrostatic potential fluctuation spectrum in the NASA Lewis bumpy-torus plasma was studied with capacitive probes in the low pressure (high impedance) mode and in the high pressure (low impedance) mode.
Hong, J. Y., Krawczonek, W. M., Powers, E. J., Roth, J. R., Singh, C. M.   +4 more
core   +1 more source

Vacuum radiation pressure fluctuations on electrons

Physical Review D
This paper is a continuation of a study of the properties and applications of quantum stress tensor fluctuations. Here we treat the vacuum fluctuations of the electromagnetic energy-momentum flux operator which has been averaged in space and time. The probability distribution of these fluctuations depends upon the details of this averaging and may ...
openaire   +2 more sources