Results 131 to 140 of about 91,606 (298)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Pressure fluctuation around chute blocks of SAF stilling basins

, 2010
Geometry of the chute blocks in stilling basins plays a significant role in size and type of these structures. One of the most influencing factors in the design of the blocks is the fluctuating pressure which may cause fatigue on the blocks.
Najdat Aziz (19586935), S M Sadat-Helbar (20195997), Javad Farhoudi (20123826)   +2 more
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The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults. [PDF]

J Gerontol A Biol Sci Med Sci, 2022
Jiang X, Cai Y, Wu X, Huang B, Chen Y, Zhong L, Gao X, Guo Y, Zhou J.   +8 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults. [PDF]

Front Cardiovasc Med, 2022
Jiang X, Cai Y, Wu X, Huang B, Chen Y, Zhong L, Gao X, Guo Y, Zhou J.   +8 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Research on pressure fluctuation distribution law and rotor-stator interaction of pump-turbine in vaneless region of turbine mode

Frontiers in Energy Research
The vibration issue of pumped storage power station unit will directly affect the safe and stable operation of the unit, and the pressure pulsation in the vaneless region is an important index to evaluate the stability of the unit.
Chuanbao Yi, Chuanbao Yi, Zequan Zhang, Haiyang Dong, Yonggang Lu, Shuangquan Xu, Xiji Li, Chuanzhen Sun, Shuaishuai Zhang, Zhengwei Wang   +9 more
doaj   +1 more source

Effects of Continuous Positive Airway Pressure Therapy on Nocturnal Blood Pressure Fluctuation Patterns in Patients with Obstructive Sleep Apnea. [PDF]

Int J Environ Res Public Health, 2022
Kumagai H, Sawatari H, Hoshino T, Konishi N, Kiyohara Y, Kawaguchi K, Murase Y, Urabe A, Arita A, Shiomi T.   +9 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Determination of minimum fluidization velocity by pressure fluctuation measurement

, 1995
Using the standard deviation of pressure fluctuations to find the minimum fluidization velocity, Umf, avoids the need to de-fluidize the bed so Umf can be found for operational bubbling fluidized beds without disrupting the process provided only that the
Wilkinson, Derek
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