Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
PRESSURE GROUPS – THE ALLIES OF THE CITIZENS, OF THE POLITICIANS OR JUST DEDICATED TO THEIR OWN CAUSE? [PDF]
We, the people leaving in democratic societies, have come across information about pressure groups or interest groups and political interests coming together under the usually harmless terms of “in the help of every single citizen”, but very often ...
Raluca Mihaila
core
The invariant rings of the Sylow groups of GU(3,q2), GU(4,q2), Sp(4,q) and O+(4,q) in the natural characteristic [PDF]
Let G be a Sylow p -subgroup of the unitary groups GU(3,q2)GU(3,q2), GU(4,q2)GU(4,q2), the symplectic group Sp(4,q)Sp(4,q) and, for q odd, the orthogonal group O+(4,q)O+(4,q).
Fleischmann, Peter +2 more
core +1 more source
Carbon quantum dots (CDs) with favorable fluorescent properties have stimulated considerable effort to modulate their photoluminescence (PL) for bioimaging and sensing.
Junfeng Ding (1741888) +6 more
core +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On state autonomy : pressure groups and public policy in Britain and Spain in a comparative perspective, 1830s-1930s [PDF]
The paper looks into the relationship between industrial pressure groups and the state, comparing the experiences of Britain and Spain during the 19th and the first third of the 20th century.
Juan Carlos Rojo Cagigal
core
Inter-rater reliability of the EPUAP pressure ulcer classification system using photographs [PDF]
Background. Many classification systems for grading pressure ulcers are discussed in the literature. Correct identification and classification of a pressure ulcer is important for accurate reporting of the magnitude of the problem, and for timely ...
Tom Defloor +6 more
core +1 more source
Informational Lobbying under the Shadow of Political Pressure [PDF]
We examine the incentives of an interest group to provide verifiable policy-relevant information to a political decision-maker and to exert political pressure on her. We show that both lobbying instruments are interdependent.
Matthias Dahm, Nicolas Porteiro
core +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source

