Results 31 to 40 of about 20,946 (263)

Driving pulsation analysis of electro-hydraulic robot

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
The hydraulic driving source plays an important role in the performance of the electro-hydraulic robot. In this paper, the Lumped parameter method is used to establish the pressure-flow characteristic model of the constant pressure variable pump of a 6 ...
Changyou ZHANG, Guangzhu CHEN, Changwei MIAO, Yingjie TANG, Nan BAI   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Experimental study of effects of buffer tank volume on pressure pulsation in valved linear compressor's pipe system at different frequencies

Xibei Gongye Daxue Xuebao
The valved linear compressor (VLC) is an essential part of the Joule-Thompson (J-T) throttling cryocooler in the liquid helium temperature region. The pressure pulsation may cause the fluctuation of the temperature and cooling capacity of the cryocooler,
HUANG Qi, DING Lei, SHA Xinquan, LI Zicheng, LIU Shaoshuai, JIANG Zhenhua, DONG Deping   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Numerical analysis of pressure pulsation in vertical submersible axial flow pump device under bidirectional operation

AIP Advances, 2022
In order to analyze the pressure pulsation characteristics of a single-conduit vertical submersible axial-flow pump device under bidirectional operation, the unsteady numerical simulation of the pump device was carried out based on computational fluid ...
Fan Yang, Pengcheng Chang, Chao Li, Qiangru Shen, Jun Qian, Jindong Li   +5 more
doaj   +1 more source

Research on non-uniform pressure pulsation of the diffuser in a nuclear reactor coolant pump

Nuclear Engineering and Technology, 2021
The nuclear reactor coolant pump transferring heat energy inherently brings with it the unsteady flow and inevitably threatens to the safe operation of the pump unit, especially with the pressure pulsation induced by the rotor-stator interaction. In this
Qiang Zhou, Hongkun Li, Lin Pei, Zuowen Zhong   +3 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Effect of Venous Pressure on Volume Pulsation

Experimental Biology and Medicine, 1939
In a previous study it was noted that, with ligation of the main venous outlet from the lower extremity of the dog, a marked reduction in peripheral pulse volume occurred.1 The present observations were made to throw some light on the mechanism of these changes.In 14 dogs the volume of pulsations in the hind foot was determined by adapting a specially ...
G. E. Burch, M. DeBakey, W. A. Sodeman
openaire   +1 more source