Results 41 to 50 of about 23,488 (225)

Flow Pulsation Characteristic of External Gear Pump and Analysis of Influencing Factor

Jixie chuandong, 2020
Based on the bench test of oil pump， the influence of pump outlet pressure on flow pulsation of external gear oil pump is analyzed. The results show that the flow pulsation coefficient of the oil pump decreased with the increase of pump outlet pressure ...
Liangyi Shen, Lei Qu, Biao Shen
doaj  

Driving pulsation analysis of electro-hydraulic robot

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
The hydraulic driving source plays an important role in the performance of the electro-hydraulic robot. In this paper, the Lumped parameter method is used to establish the pressure-flow characteristic model of the constant pressure variable pump of a 6 ...
Changyou ZHANG, Guangzhu CHEN, Changwei MIAO, Yingjie TANG, Nan BAI   +4 more
doaj   +1 more source

Pressure Pulsation of High Consistency Machine Screening

, 2023
Pressure fluctuation on headbox slice flow causes basis weight variation in machine direction and quality issues to end product. Machine screen is a typical source of short-term and recurring pressure fluctuation and pulsation.
Silakoski, Ville
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Semi-active accumulator absorbing pressure pulsation in high-pressure water-jet propulsion system

, 2011
Large-capacity and high-pressure plunger water-pump is often used as power supply in high-pressure water-jet propulsion system (HWPS). Generally, the flow pulsation and pressure pulsation generated in the working process of HWPS is absorbed by a passive
Z Niu, J Hu, X Luo, Z Shi
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Research on non-uniform pressure pulsation of the diffuser in a nuclear reactor coolant pump

Nuclear Engineering and Technology, 2021
The nuclear reactor coolant pump transferring heat energy inherently brings with it the unsteady flow and inevitably threatens to the safe operation of the pump unit, especially with the pressure pulsation induced by the rotor-stator interaction. In this
Qiang Zhou, Hongkun Li, Lin Pei, Zuowen Zhong   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source