Results 41 to 50 of about 2,480,861 (247)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Driving pulsation analysis of electro-hydraulic robot

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
The hydraulic driving source plays an important role in the performance of the electro-hydraulic robot. In this paper, the Lumped parameter method is used to establish the pressure-flow characteristic model of the constant pressure variable pump of a 6 ...
Changyou ZHANG, Guangzhu CHEN, Changwei MIAO, Yingjie TANG, Nan BAI   +4 more
doaj   +1 more source

Pressure Pulsation of High Consistency Machine Screening

, 2023
Pressure fluctuation on headbox slice flow causes basis weight variation in machine direction and quality issues to end product. Machine screen is a typical source of short-term and recurring pressure fluctuation and pulsation.
Silakoski, Ville
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Semi-active accumulator absorbing pressure pulsation in high-pressure water-jet propulsion system

, 2011
Large-capacity and high-pressure plunger water-pump is often used as power supply in high-pressure water-jet propulsion system (HWPS). Generally, the flow pulsation and pressure pulsation generated in the working process of HWPS is absorbed by a passive
Z Niu, J Hu, X Luo, Z Shi
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Research on non-uniform pressure pulsation of the diffuser in a nuclear reactor coolant pump

Nuclear Engineering and Technology, 2021
The nuclear reactor coolant pump transferring heat energy inherently brings with it the unsteady flow and inevitably threatens to the safe operation of the pump unit, especially with the pressure pulsation induced by the rotor-stator interaction. In this
Qiang Zhou, Hongkun Li, Lin Pei, Zuowen Zhong   +3 more
doaj   +1 more source

Internal fibre length concentration in a pressure screen [PDF]

, 2007
Localised axial consistency profiles within a pressure screen of a Pinus Radiata kraft pulp are reported. Axial Samples were also analysed using a Kajaani FS-200 to obtain fibre length distribution data.
Walmsley, Michael R.W., Weeds, Zuben, Atkins, Martin John   +2 more
core