Results 41 to 50 of about 3,192,729 (295)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Existence of eigenvalues of a linear operator pencil in a curved waveguide - localized shelf waves on a curved coast [PDF]

, 2006
The question of the existence of nonpropagating, trapped continental shelf waves (CSWs) along curved coasts reduces mathematically to a spectral problem for a self-adjoint operator pencil in a curved strip.
Johnson, E R, Parnovski, L, Johnson, E.R., Levitin, M., Parnovski, Leonid, Parnovski, L., Levitin, Michael, Johnson, E. R.   +7 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Seabed Dynamic Responses Induced by Nonlinear Internal Waves: New Insights and Future Directions

Journal of Marine Science and Engineering, 2023
Strong nonlinear internal waves generate a significant pressure force on the seafloor and induce a pore-pressure response penetrated in the seabed and are thus an important driver of sediment resuspension and a potential trigger of seabed failure.
Tian Chen, Zhenghui Li, Hui Nai, Hanlu Liu, Hongxian Shan, Yonggang Jia   +5 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Influence of Chemical Kinetics on Tulip Flame Formation in Highly Reactive (H₂/Air) and Low Reactive (CH₄/Air) Mixtures

Energies
The early stages of hydrogen–air and methane–air flame dynamics and the development and evolution of tulip flames in closed tubes of various aspect ratios and in a semi-open tube are studied by solving the fully compressible reactive Navier–Stokes ...
Chengeng Qian, Mikhail A. Liberman
doaj   +1 more source

Numerical investigation on jet characteristics and performance of SparkJet actuator based on pressure wave behavior inside a cavity

AIP Advances, 2020
Thrust and total impulse performance of a SparkJet actuator are affected by pressure waves inside the cavity, so it is important to understand these effects.
Hyung-Jin Kim, Jin Young Shin, Jeongheon Chae, Sangjun Ahn, Kyu Hong Kim   +4 more
doaj   +1 more source

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

Experimental Identification of a New Secondary Wave Pattern in Transonic Cascades with Porous Walls

Aerospace
Turbomachinery shock wave patterns occur as a natural result of operating at off-design points and are accountable for some of the loss in performance. In some cases, shock wave–boundary layer (SW-BLIs) interactions may even lead to map restrictions. The
Valeriu Drăgan, Oana Dumitrescu, Mihnea Gall, Emilia Georgiana Prisăcariu, Bogdan Gherman   +4 more
doaj   +1 more source