Results 41 to 50 of about 174,900 (265)

Species-rich but defaunated: the case of medium and large-bodied mammals in a sustainable use protected area in the Amazon

Acta Amazonica, 2021
Neotropical medium and large-bodied mammals are key elements in forest ecosystems, and protected areas are essential for their conservation. In Brazil, sustainable use protected areas (SU-PAs) allow both the conservation of biodiversity and the ...
Dian Carlos Pinheiro ROSA, Carlos Rodrigo BROCARDO, Clarissa ROSA, Arlison Bezerra CASTRO, Darren NORRIS, Rodrigo FADINI   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Recent pace of change in human impact on the world's ocean. [PDF]

, 2019
Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ...
Afflerbach, Jamie, Frazier, Melanie, Halpern, Benjamin S, Lowndes, Julia S, Micheli, Fiorenza, O'Hara, Casey, Scarborough, Courtney, Selkoe, Kimberly A   +7 more
core  

Editorial: Bridging the gap between policy and science in assessing the health status of marine ecosystems [PDF]

, 2016
Human activities,both established and emerging, increasingly affect the provision of marine ecosystem services that deliver societal and economic benefits.
Austen, Melanie, Berg, Torsten, Borja, Angel, Carstensen, Jacob, Cochrane, Sabine, Danovaro, Roberto, Elliott, Mike, Greenstreet, Simon, Heiskanen, Anna-Stiina, Lynam, Christop, Snelgrove, Paul   +10 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Impact chains for the deep seafloor: assessing pressures footprint under limited knowledge and uncertainty

Frontiers in Marine Science
Pressures on the marine environment threaten biodiversity, ecosystem functions and services. Current marine environmental policies, such as the European Marine Strategy Framework Directive, require the assessment of combined effects and the application ...
Fábio L. Matos, Ana Hilário, Heliana Teixeira   +2 more
doaj   +1 more source

A review of Australian approaches for monitoring, assessing and reporting estuarine condition: I. International context and evaluation criteria [PDF]

, 2016
© 2016 Elsevier Ltd Given the immeasurable value of estuaries and their severe and growing pressures, sound understanding and reporting of estuarine condition is essential for their effective management and sustainable development.
Elliott, Mike, Hallett, Chris S., Valesini, Fiona   +2 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Interaction of Ladle Slag With Varying SiO2 Content and Recyclate‐Based MgO–C Refractories

Advanced Engineering Materials, EarlyView.
Ladle slags (CaO/Al2O3 = 1) with 1–20 wt% SiO2 were investigated in contact with industrial MgO–C refractories fabricated from fresh magnesia and 50 wt% recyclate. The sessile drop method at 1600°C reveals intensive gas formation, delayed slag infiltration in recyclate‐based samples, and, under high‐SiO2 slag, formation of a dense MgAl2O4‐rich ...
Anton Yehorov, Eldar Salpagarov, Anhelina Mospan, Till Manon Jannis Stadtmüller, Thomas Schemmel, Christos Georgios Aneziris, Olena Volkova   +6 more
wiley   +1 more source