Results 51 to 60 of about 14,747 (270)

Exploring Vulnerability Indicators: Tourist Impact on Cultural Heritage Sites in High Arctic Svalbard

Heritage, 2023
This article reports findings from two research projects that aimed to understand the vulnerabilities of cultural heritage sites in Svalbard and investigated factors that influence tourism-induced pressures and site degradation.
Anne Cathrine Flyen, Cecilie Flyen, Atle Wehn Hegnes   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Impact chains for the deep seafloor: assessing pressures footprint under limited knowledge and uncertainty

Frontiers in Marine Science
Pressures on the marine environment threaten biodiversity, ecosystem functions and services. Current marine environmental policies, such as the European Marine Strategy Framework Directive, require the assessment of combined effects and the application ...
Fábio L. Matos, Ana Hilário, Heliana Teixeira   +2 more
doaj   +1 more source

Species-rich but defaunated: the case of medium and large-bodied mammals in a sustainable use protected area in the Amazon

Acta Amazonica, 2021
Neotropical medium and large-bodied mammals are key elements in forest ecosystems, and protected areas are essential for their conservation. In Brazil, sustainable use protected areas (SU-PAs) allow both the conservation of biodiversity and the ...
Dian Carlos Pinheiro ROSA, Carlos Rodrigo BROCARDO, Clarissa ROSA, Arlison Bezerra CASTRO, Darren NORRIS, Rodrigo FADINI   +5 more
doaj   +1 more source

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, EarlyView.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source

Multiple global‐change drivers and cascading effects in Mediterranean ecosystems: Lessons from an iconic national park

Conservation Science and Practice
Historically, Mediterranean systems, particularly the Mediterranean Basin, have been substantially impacted by multiple regional‐scale disturbances resulting from complex interactive effects of global‐change drivers.
Maria Paniw, Duarte S. Viana, Cristina Coccia, Virginia Domínguez‐García, Iñigo Donázar‐Aramendía, Sebastiano deFranciscis, Alberto García‐Rodríguez, Simone Guareschi, Pablo Homet, Jose B. Lanuza, Cosme López‐Calderón, Irene Mendoza, Eva Moracho, Laetitia M. Navarro, Javier Puy, José M. Reyes‐González, María José Ruiz‐López, Zulima Tablado, Elena Tena, Estefanía Tobajas, Elena Velado‐Alonso, Pablo Villalva, Nacho Villar, Marcello D'Amico   +23 more
doaj   +1 more source

Mesophotic ecosystems : distribution, impacts and conservation in the South Atlantic [PDF]

, 2019
Unidad de excelencia María de Maeztu MdM-2015-0552Aim: this study reviews recent research on the South Atlantic Mesophotic ecosystems (MEs) and the pressures threatening them, and offers suggestions for their management and conservation.
Soares, Marcelo de Oliveira, Carneiro, Pedro Bastos de Macêdo, Tavares, Tallita Cruz Lopes   +2 more
core   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source