This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Safety and efficacy of a feed additive consisting of <i>Lactococcus lactis</i>DSM 34262 as an acidity regulator additive for all animal species (Lactosan GmbH & Co.KG). [PDF]
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +23 more
europepmc +1 more source
Presumptions for E-leadership in Local Self-Government in Lithuania
Rita Toleikienė, Vita Juknevičienė
openalex +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Safety and efficacy of a feed additive consisting of <i>Lactiplantibacillus plantarum</i> DSM 34271 as an acidity regulator additive for all animal species (Lactosan GmbH & Co.KG). [PDF]
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +23 more
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Safety and efficacy of a feed additive consisting of <i>Pediococcus pentosaceus</i>NCIMB 12674 for all animal species (Danstar Ferment AG). [PDF]
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +21 more
europepmc +1 more source

