Results 111 to 120 of about 56,302 (303)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Alauddin Law Development JournalThis study aims to determine the contradiction between the provisions on the proof of the original criminal act with the principle of Presumption of Innocence in the Anti-Money Laundering Law 2010.
Fadli Yasser Arafat J. +3 more
doaj +1 more source
PRESUMPTION OF INNOCENCE OF LEGAL PERSONS
Administrative and Criminal Justice, 2016 There is a link between a presumption of innocence and the right to a fair trial. The rights of a legal person, to be regarded as innocent, protection is ensured by the guarantees in law. The Court of Justice has recognized that the right to the presumption of innocence, the legal persons does not apply in the same way as natural persons.
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Kidney Sales and the Burden of Proof [PDF]
, 2019 Janet Radcliffe Richards’ The Ethics of Transplants outlines a novel framework for moral inquiry in practical contexts and applies it to the topic of paid living kidney donation.
Koplin, Julian, Selgelid, Michael
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Конституційно-правові академічні студіїThe purpose of the article is to determine, taking into account the results of the analysis of the current legislation of Ukraine and the provisions of the doctrine of criminal law, the issues of correlation and ensuring the compliance of the ...
Yaroslav Stupnyk, Maryna Stupnyk
doaj +1 more source
Maryland v. King: The Fourth Amendment Spirals Down the Double Helix [PDF]
, 2013 This commentary previews an upcoming Supreme Court case, Maryland v. King, in which the Court may decide whether requiring an arrestee to submit to a buccal swab for identification purposes violates the arrestee\u27s privacy interests under the Fourth ...
Witanachchi, Sitara V.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Travessias, 2013 This research will seek to analyze, through a study of jurisprudence and doctrinal understanding as constitutional by the Supreme Court in the trial of Habeas 84,078, which declared unconstitutional the provisional execution of the sentence and the ...
Bruno Rafael Cipriano, Ricardo Feistler
doaj